このエントリーをはてなブックマークに追加
ID 13172
Eprint ID
13172
FullText URL
Thumnail 119_17.pdf 258 KB
Title Alternative
Molecular mechanism on Cdk5-dependent insulin secretion
Author
魏 范研
長嶋 一昭
大島 登志男
佐伯 恭範
陸 雲飛
松下 正之
山田 祐一郎
御子柴 克彦
清野 裕
富澤 一仁
Keywords
Insulin
Cdk5
Calcium
Note
平成17年度岡山医学会賞(結城賞)受賞論文
Published Date
2007-05-01
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume119
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
17
End Page
20
ISSN
00301558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
1) Inagaki N, et al. : Reconstitution of IKATP : an inward rectifier subunit plus the sulfonylurea receptor. Science (1995) 270, 1166-1170.
2) Bratanova-Tochkova TK, et al. : Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes (2002) 51, S83-90.
3) Moller DE : New drug targets for type 2 diabetes and the metabolic syndrome. Nature (2001) 414, 821-827.
4) Tsai LH, Takahashi T, Caviness VS Jr, Harlow E : Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development (1993) 119, 1029-1040.
5) Lew J, et al. : A brain-specific activator of cyclin-dependent kinase 5. Nature (1994) 371, 423-426.
6) Cruz JC, Tsai LH : A Jekyll and Hyde kinase : roles for Cdk5 in brain development and disease. Curr Opin Neurobiol (2004) 14, 390-394.
7) Ohshima T, et al. : Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci USA (2001) 98, 2764-2769.
8) Tomizawa K, et al. : Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J Neurosci (2002) 22, 2590-2597.
9) Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E : p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature (1994) 371, 419-423.
10) Tang D, et al. : An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. J Biol Chem (1995) 270, 26897-26903.
11) Wei FY, et al. : Cdk5 dependent regulation of glucose-stimulated insulin secretion. Nat Med (2005) 11, 1104.
12) Ubeda M, Kemp DM, Habener JF : Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells. Endocrinology (2004) 145, 3023-3031.
language
日本語
OAI-PMH Set
岡山大学
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
DOI
Sort Key
4
Eprints Journal Name
joma