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ID 14085
Eprint ID
14085
FullText URL
Thumnail 106_517.pdf 423 KB
Title Alternative
Studies on the cause of intractable asthma using animal model Part 1. Establishment of a chronic asthma model by repeated antigen inhalation
Author
Sugano, Hisashi
Abstract
To elucidate the cause of intractable asthma, guinea pigs were actively sensitized by intraperitoneal injection of ascaris suum as an antigen. We repeated the inhalation of aerosolized ascaris antigen eight times in the animal models which consisted of a non-treated group, a metopirone-treated group and a steroid-treated group. We investigated the course of asthmatic response by evaluating the ratio of expirations to inspirations after the inhalation challenge. The frequency of late asthmatic response (LAR) was increased by repeated inhalation of the antigen. There was no significant differnce in the frequency between non-treated group and steroid-treated group, but the metopirone-treated group showed strong LAR compared with the other two groups. The intensity of LAR was gradually increased and that of immediate asthmatic response (LAR) was decreased in the metopirone-treated group. Finally, we established a chronic asthma model in which LAR was strong and the asthma attack was prolonged over twenty-four hours. These results suggest that the model will be useful in clarifying the causes of intractable asthma in humans.
Keywords
chronic asthma
animal model
guinea pig
re-inhalation
late asthmatic response
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
517
End Page
525
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
http://www.journalarchive.jst.go.jp/japanese/jnlabstract_ja.php?cdjournal=joma1947&cdvol=106&noissue=5-6&startpage=517
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma