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ID 14728
Eprint ID
14728
FullText URL
102_299.pdf 644 KB
Title Alternative
Clinical and experimental studies on provocating and reducing mechanism of intractable pain Part 2. β-endorphin and monoamine metabolites in CSF of the patient with chronic pain -comparison of the concentration between pre- and post-stimulation of CNS
Author
Fujiwara, Noriaki
Abstract
The concentration of β-endorphin-immunoreactivity (β-END-IR) and monoamine metabolites which are 3-methoxy-4-hydroxy-phenylglycol (MHPG), homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF) of patients with intractable pain to estimate the participation of these substances in the mechanism of intractable pain. The amount of β-END-IR and monoamine metabolites was measured with radioimmunoas-say and HPLC (hight performance liquid chromatography), respectively. Eight cases of intractable pain were treated with impantation of the stimulating electrode for pain relief. This treatment was performed in 2 ways, deep brain stimulation (DBS) done on 6 cases and spinal dorsal column stimualtion (DCS) on 2 cases. The concentrations of β-END-IR and monoamine metabolites were also estimated before and after the stimulation. No patient treated with DBS showed the elevation of β-END-IR or monoamine metabolites after the stimulation, except for one patient who showed significant increase of monoamine metabolites accompanying excellent pain relief by the stimulation. On the other hand, the two patients treated with DCS indicated significant elevation of β-END-IR as well as monoamine metabolites. Thus, both β-END and monoamines could play as important role DCS, and that monoamine could be involved in DBS for pain relief.
Keywords
β-endorphin
monoamine
pain
CSF
stimulation of CNS
Published Date
1990-04
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
299
End Page
308
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/3-4/102_3-4_299/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma