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ID 15167
Eprint ID
15167
FullText URL
Title Alternative
A case of rheumatoid arthritis with hypoproteinemia probably induced by diseasemodifying antirheumatic drug, D-Penicillamine
Author
Kitani, Hikaru
Mifune, Takashi
Okazaki, Morihiro
Tanizaki, Yoshiro
Abstract
症例は52歳女性で,慢性関節リウマチ(RA)はclassical,stageIV, class 2であった。症状は進行性で加療を行うも改善がみられなかった。平成元年11月RA症状の増悪のための再入院後,Penicillamine 100~200 mg,Sulfasalazine 500mgを合せて投与を行ったところ,血沈,CRP等の検査所見は改善傾向を示したが入院時には正常値であった血清蛋白量がその後5.1g/dlまで低下し,下肢浮腫が出現,その後さらに血清蛋白量は4.1g/dlにまで減少した。治療により蛋白量は5.8g/dlにまで回復したが,低蛋白血症の原因としてはD-Penicillamineの関与が疑われた。
Abstract Alternative
A patient with classical rheumatoid arthritis was treated with D-Penicillamine and other drugs. In the course of treatment, the episodes of hypoproteinemia were found twice. The first hypoproteinemia was improved almostly by supportive therapy and withdrawl of administration of medicines, including D-Penicillamine. The second hypoproteinemia was severe and resistant to the treatment. It was suggested that the agent eliciting hypoproteinemia in this case might be D-Penicillamine.
Keywords
慢性関節リウマチ (Rheumatoid arthritis)
低蛋白血症 (Hypoproteinemia)
D-ペニシラミン (D-Penicittamine)
抗リウマチ剤 (Disease-modifying antirheumatic drug)
Published Date
1991-08
Publication Title
環境病態研報告
Publication Title Alternative
Papers of the Institute for Environmental Medicine, Okayama University Medical Scool
Volume
volume62
Publisher
岡山大学医学部附属環境病態研究施設, 岡山大学医学部附属病院三朝分院
Publisher Alternative
Institute for Environmental Medicine, Okayama University Medical Scool
Start Page
80
End Page
83
ISSN
0913-3771
NCID
AN10084718
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc