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ID 15952
Eprint ID
15952
FullText URL
99_751.pdf 1.07 MB
Title Alternative
Uptake and release of 5-hydroxytryptamine and taurine in the cerebral cortex of El mice
Author
Ogawa, Kazutoshi
Abstract
El mice are epileptic mice in which convulsive seizures are easily induced by throwing stimulation. Uptake and release of [(3)H] 5-hydroxytryptamine and [(3)H] taurine were examined in cerebral cortical slices of non-stimulated El mice [El(-)], stimulated El mice [El(+)] during the interictal period and ddY mice (ddY), which are the mother strain of El mice and do not have a convulsive disposition. Release was defined as 40mMK(+)-stimulated release. Uptake of 5-HT and taurine was lower in El(+) than in El(-), but no significant difference was found between ddY and El(-). Release of 5-HT and taurine was higher in El(-) than in either ddY or El(+). No significant difference in spontaneous release of 5-HT and taurine was found between ddY, El(-) and El(+). The taurine level in El(-) and El(+) was higher than in ddY, but no significant difference was found between El(-) and El(+). These results suggest that low uptake and release of 5-HT and taurine may increase seizure susceptibility in El(+).
Keywords
El mouse
大脳皮質
5-hydroxytryptamineとtaurine
uptakeとrelease
けいれん準備性
Published Date
1987-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
751
End Page
761
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_751/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma