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ID 16017
Eprint ID
16017
FullText URL
Thumnail 100_885.pdf 570 KB
Title Alternative
Studies on superoxide anion production by human monocytes Part 1. The effect of aging
Author
Mishima, Yasuo
Abstract
Superoxide anion (O(-)(2)) plays an important role in the bactericidal activity of human monocytes. Stimulation of human monocytes by concanavalin A (Con A) and cytochalasin E (Cyt E) results in superoxide production. In this study, the O(-)(2) generation of monocytes was assessed for variation with age. Monocytes obtained from 51 normal subjects were assessed.The optimal concentrations of Cyt E and Con A were 20μg/ml and 100μg/ml, respectively. There was no significant difference in O(-)(2) production between males and females. O(-)(2) production in older subjects (65-86years) was significantly lower than that in younger subjects (20-64years)(p<0.05). The values were 11.2±3.3 nmol/min/10(6) cells in the former, and 12.9±2.6 nmol/min/10(6) cells in the latter. These findings suggest that impaired O(-)(2) production might be one of the factors accounting for the impaired bactericidal activity of mononuclear leucocytes in the aged.
Keywords
スーパーオキサイド
単球
加齢
Published Date
1988
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume100
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
885
End Page
893
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/100/9-10/100_9-10_885/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma