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ID 16156
Eprint ID
16156
FullText URL
Thumnail 98_135.pdf 898 KB
Title Alternative
Metabolic role of the kidney in acute hepatic failure (Guanidino compounds and the metabolic relationship between the liver and kidney)
Author
Nishitani, Kyoko
Abstract
A metabolic relationship between the liver and kidney exists in conbination with the urea cycle. We found different concentrations of serum guandino compounds between patients with acute renal failure and those with acute hepatic failure. We made an experimental model of acute hepatic failure in rats by injecting 1,000 mg/kg of D-galctosamine i. p. and evaluated the metabolic changes in the liver and kidney by measuring guandino compound levels using high performance liquid chromatography. We concluded that when the urea cycle was disturbed, the metabolism in the kidney was activated, and the synthesis of GAA (guandino acetic acid) was accelerated for the purpose of excreting ammonium. Also, we thought it possible to evaluate the metabolic compensative ability of the kidney by determining (serum Arginine)/(serum GAA). In the liver and kidney of rats, we found high levels of GBA (guanidino butyric acid), the metabolic pathway of which is unknown. With the progress of liver damage, the release of GBA into the serum was observed.
Keywords
急性肝不全
尿素サイクル
アルギニン
グアニジノ酢酸
グアニジノ酪酸
Published Date
1986-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume98
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
135
End Page
143
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/98/1-2/98_1-2_135/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma