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ID 16524
Eprint ID
16524
FullText URL
Thumnail 93_219.pdf 316 KB
Title Alternative
Experimental Study on Inorganic manganease and Organic manganease(MMT) intoxication 1 Comparison between the effects of MMT and MnCl(2) on oxidative phosphorylation of isolated rat liver mitochondria
Author
Morita, Keijiro
Abstract
Methylcyclopentadienyl manganease tricarbonyl (MMT) has been developed and used increasingly as a replacement for tetraethyl lead which has been widely used as an antiknock agent of gasoline, or as a fuel oil combustion improver. We, therefore, investigated the effect of MMT on oxidative phosphorylation and K release of mitochondria as an index of toxic effects on biomembranes. The concentrations of solution used were 0.10, 0.25, 0.40 and 0.50 mM. Results obtained were as follows. 1. MMT activated state 4 respiration at more than 0.20 mM solution, i.e. showing the uncoupling phenomenon. 2. Mitochondrial oxidative phosphorylation with MMT was greater than with MnCl. 3. Both MMT and MnCl(2) induced K release from mitochondria, and a dose-response relationship between K release and MMT was recognized. 4. It was considered that one reason for the remarkable difference in uncoupling between MMT and MnCl(2) was the difference in lipid affinity.
Keywords
メチルシクロペンタジェニルマンガン
塩化マンガン
ミトコンドリア
酸化的リン酸化
K(+)遊出
Published Date
1981-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume93
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
219
End Page
225
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/93/3-4/93_3-4_219/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma