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ID 16620
Eprint ID
16620
FullText URL
Thumnail 96_1163.pdf 3.41 MB
Title Alternative
Studies on the pathogenesis of sarcoidosis Part Ⅱ. Experimental pulmonary granulomatosis produced by Corynebacterium parvum and Muramyl dipeptide.
Author
Kobayashi, Yhozo
Abstract
Propionibacterium acnes (P.acnes) is isolated in high incidence from biopsied specimens obtained from patients with sarcoidosis. In some reports, P.acnes successfully produced localized granulomatous changes in experimental animals, but not systemic granulomatous changes. The present study was undertaken to analyze the formation of granulomatous lesions, especially the immunological mechanism of epithelioid granuloma formation, induced by sensitization with Corynebacterium parvum (C.parvum) and muramyl dipeptide (MDP). Intratracheal administration of MDP to guinea pigs presensitized with C.parvum produced epithelioid granulomas in the lungs and regional lymph nodes, but not in the liver and spleen. These granulomas in the lungs gradually invated regional lymph nodes and were observed a relatively long time, as the patients with sarcoidosis. An increase in lymphocytes was found in bronchoalveolar lavage fluid of sensitized animals in accordance with granuloma formation in the lungs. This result suggests that lymphocytes play a major role in producing epithelioid granulomas. Serum angiotensin converting enzyme activity was elevated in guinea pigs, in which granuloma formation was recognized. These data suggest that activation of macrophages and lymphocytes is necessary to produce epithelioid granulomas and persists for a long time in experimental animals.
Keywords
experimental animal model
sarcoidosis
Corynebacterium
parvum
muramyl dipeptide
angiotensin converting enzyme
Published Date
1984-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1163
End Page
1174
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/11-12/96_11-12_1163/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma