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ID 16630
Eprint ID
16630
FullText URL
Thumnail 96_1183.pdf 576 KB
Title Alternative
Studies on anticancer agent-monoclonal antibody conjugates Part I. Production of anti-HLA monoclonal antibody-BLM, -MMC, -MCR conjugates and their biological activities
Author
Manabe, Yuichi
Abstract
Bleomycin (BLM) and mitomycin C (MMC), potent anticancer agents, were linked covalently to murine monoclonal anti-HLA IgG(1) antibody (H-1) with the use of dextran T-40. Macromomycin (MCR) was coupled to H-1 in the presence of carbodiimide. H-1 alone did not inhihit cell growth. BLM-(H-1) and MMC-(H-1) conjugates showed stronger cytotoxicity to an HLA-bearing cell line than BLM and MMC, respectively. MCR-(H-1) and free MCR showed the same cytotoxicity to HLA-bearing cells, while the conjugate was less toxic than free MCR against cells lacking HLA. These results indicate that BLM-(H-1), MMC-(H-1) and MCR-(H-1) exert antibody-targeting cytotoxicity in vitro.
Keywords
抗HLAモノクロナール抗体
bleomycin
mitomycin C
macromomycin
Published Date
1984-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1183
End Page
1193
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/11-12/96_11-12_1183/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma