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ID 16873
Eprint ID
16873
FullText URL
Thumnail 91_567.pdf 443 KB
Title Alternative
Effect of B.C.G. and Splenectomy on survival prolongation of mice with Ehrlich ascites cancer
Author
Hashimoto, Masaaki
Abstract
In this report, an effective way of B.C.G. in combination with splenectomy is presented for cancer therapy. Ehrlich ascites cancer was inoculated into the footpads of DDS mice. At the appropriate times of tumor growth, a femur was amputated to remove the primary tumor. After several days, the host was rechallenged with Ehrlich ascites cancer. The challange was considered as metastasis. For the first experiments, mice were injected with B.C.G. into primary inoculated tumor and also splenectomized at the amputation. The combined therapy of B.C.G. injection and splenectomy prolonged survival, whereas neither B.C.G. injection nor splenectomy alone did not. For the next examination, the influence of B.C.G. presensitization with or without splenectomy on survival was examined. It was confirmed that the combined therapy was useful for the prolongation of survival. Furthermore, when Ehrlich ascites cancer was reinoculated with sera obtained from tumor bearing mice, splenectomy effectively prolonged survival. The data suggest that B.C.G. therapy is effective for host survival, especially when splenectomy is also performed.
Keywords
BCG
摘脾
エールリッヒ癌
DDSマウス
Published Date
1979-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
567
End Page
575
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/5-6/91_5-6_567/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma