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ID 16949
Eprint ID
16949
FullText URL
Thumnail 91_893.pdf 1.71 MB
Title Alternative
Regional CO(2) reactivity under acute intracranial hypertension due to a space occupying lesion
Author
Okao, Shojiro
Abstract
Regional CO(2) reactivity of different areas were observed during acute intracranial hypertension produced by extradural balloon compression in dogs. Regional CBF was measured by as heat clearance method with two thermocouple probes, 1) in the parietal area adjacent to the balloon and the contralateral parietal area, 2) in the adjacent parietal area and the ipsilateral occipital area remote from the balloon, 3) in the adjacent two areas, parietal and temporal, of the damaged hemisphere. ICP was measured by an epidural microballoon method and a fiber optic pressure switch (Ladd co.). The findings were as follows. 1. Regional CO(2) reactivity was impaired first in the area adjacent to the balloon, later in the remote area, and lastly in the contralateral area. 2. The impairment of regional CO(2) reactivity of the parietal area adjacent to the balloon and the contralateral parietal area could be classified into the following 5 stages. Stage 1: (ICP less than 20 mmHg) ICP and rCBF of both sides were increased by CO(2) inhalation. Stage 2: (ICP ca. 30 mmHg) ICP was increased more. In the contralateral area, rCBF was increased, but in the adjacent area, the increment of rCBF by CO(2) inhalation was diminished. Stage 3: (ICP ca. 45 mmHg) ICP was increased. In the contralateral area, rCBF was increased, but in the adjacent area, rCBF was decreased by CO(2) inhalation (paradoxical response i.e. intracerebral steal syndrome or intracerebral squeeze phenomenon). Stage 4: (ICP ca. 75 mmHg) ICP was increased, but rCBF on both sides was not increased by CO(2) inhalation. Stage 5: (ICP more than 100 mmHg) ICP and rCBF on both sides were not increased by CO(2) inhalation. 3. This dissociation of regional CO(2) reactivity in various areas would be caused by intracranial pressure gradients, and the consequent difference in local tissue metabolites.
Keywords
extradural balloon compression
acute intracranial hypertension
regional CO(2) reactivity
local cerebral blood flow
vasomotor tone
Published Date
1979-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
893
End Page
904
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/7-8/91_7-8_893/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma