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ID 17004
Eprint ID
17004
FullText URL
91_1427.pdf 282 KB
Title Alternative
High-performance liquid chromatographic studies of toluene and xylene poisoning Part I: Workers' exposure to toluene and xylenes estimated from metabolites in their urine in a shipyard
Author
Sugihara, Reiko
Abstract
In this paper, the author describes the determination of metabolites in the urine of shipyard workers exposed to thinner containing toluene and xylenes. Urine was taken from 4 healthy workers working at the same place, in the morning (a.m. 8:00), at noon (p.m. 0:00) and in the afternoon (p.m. 5:00), 3 times in a day for 5 consecutive days. Urinary metabolites, i.e., m-methylhippuric acid, p-methylhippuric acid and hippuric acid, were determined by high-performance liquid chromatography. The results were: 1. m-Methylhippuric acid, p-methylhippuric acid and hippuric acid in the urine of painting workers could be determined by high-performance liquid chromatography following extraction and benzoxylation. The stationary phase used in this experiment was silica gel and the mobile phase was a mixture of n-hexane and chloroform. 2. Concentrations of urinary m- and p-methylhippuric acids and hippuric acid were lowest just before, and generally highest just after, work. These results suggest that the workers were inhaling the thinner vapor even though wearing gas masks. 3. Peaks of m- and p-methylhippuric acids occurred in the chromatogram of workers' urine collected before work in the morning, although there were no peaks in the chromatogram of normal urine. This indicates that m- and p-xylenes may still remain in the workers' bodies.
Keywords
シンナー
キシレン
m-メチル馬尿酸
p-メチル馬尿酸
高速液体クロマトグラフィー
Published Date
1979-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1427
End Page
1432
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/9-10/91_9-10_1427/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma