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ID 17233
Eprint ID
17233
FullText URL
Thumnail 89_1329.pdf 10.8 MB
Title Alternative
A cytochemical study of the absorption of horseradish peroxidase through the human gastrointestinal tract
Author
Matsumoto, Teruo
Abstract
Using horseradish peroxidase (HRP) which serves as its own tracers, the absorption of intact macromolecules through the human gastrointestinal tracts was observed. In healthy volunteers, HRP was poured into the stomach, the duodenum, and the ileum through the gastric, duodenal and colonofiberscopes at several days interval. Twenty minutes after the injection, small samples of mucosa were removed. The tissues thus obtained were treated in the manner of Karnovsky and embedded in Epon and observed under an electron microscope. The absorption of HRP through the human small intestine and the intestinal metaplastic epithelia of the stomach was clearly demonstrated. Moreover, in intestinalized epithelium of the stomach, HRP was absorbed and transferred into the capillary lumen. These results indicated the posibility of absorption of macromolecules through the human gastrointestinal tract, which may be a cause of food-allergy and food poisoning. At the same time, it showed the effectiveness of oral administration of some enzyme-containing medicines. The absorption through the intestinal metaplastic epithelium was considered to be especially significant, because eaten proteins are promptly absorbed before digestion occurred.
Published Date
1977-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1329
End Page
1357
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/9-10/89_9-10_1329/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma