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ID 17693
Eprint ID
17693
FullText URL
Thumnail 88_1067.pdf 3.78 MB
Title Alternative
Neocarzinostatin effect on immune response of mice 2. Effects on cellular immunity
Author
Mikouchi, Hiroshi
Abstract
In part 2 peripheral lymphocyte count, the total number of spleen cells, the weight and histology of the spleen, in vitro proliferative response of spleen cells to phytohemagglutinin (PHA) and delayed cutaneous hypersensitivity to picryl chloride were studied to see the effects of a new antileukemic agent, Neocarzinostatin (NCS), on the cellular immunity of mice. A single administration of NCS decreased the peripheral lymphocyte count, the spleen weight, the total number of spleen cells and in vitro proliferative response to PHA on the 4(th) and 8(th) day after NCS administration but its suppressive effects on these factors almost disappeared on the 12(th) day. NCS suppressed the delayed cutaneous hypersensitivity to picryl chloride and its suppressive effect was dependent on the daily dose of NCS. But its suppressive effect weakened after 10 days of drug free interval. The above data suggest that NCS suppresses the cellular immunity of mice to a certain degree and its immunosuppressive effects are dependent on the daily dose and the number of consecutive days of NCS administration, and on the days of drug free interval.
Published Date
1976-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume88
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1067
End Page
1078
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/88/11-12/88_11-12_1067/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma