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ID 32980
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Author
Itoh, Kanako
Hashimoto, Kenji
Shimizu, Eiji
Sekine, Yoshimoto
Ozaki, Norio
Inada, Toshiya
Harano, Mutsuo
Iwata, Nakao
Komiyama, Tokutaro
Yamada, Mitsuhiko
Sora, Ichiro
Nakata, Kenji
Ujike, Hiroshi
Iyo, Masaomi
Abstract
Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C>T (C270T named formerly) in the noncoding region of exon V and 196G >A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C>T in exon V: genotype, p = 0.586, allele, p = 0.594; 196G>A (val66met) in exon XIIIA: genotype, p = 0.889, allele, p = 0.713). Furthermore, there was no difference between clinical parameters (e.g. prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C>T in exon V and 196G>A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.
Keywords
brain-derived neurotrophic factor
polymorphism
drug abuse
methamphetamine
Note
Digital Object Identifer:10.1002/ajmg.b.30097
Published with permission from the copyright holder. This is the author's copy, as published in American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, Jan 2005, Volume 132B, Issue 1, Pages 70-73.
Publisher URL:http://dx.doi.org/10.1002/ajmg.b.30097
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Copyright © 2004 Wiley-Liss, Inc. All rights reserved.
Published Date
2005-01-05
Publication Title
American Journal of Medical Genetics Part B, Neuropsychiatric Genetics
Volume
volume132B
Issue
issue1
Publisher
Wiley-Liss, Inc.
Start Page
70
End Page
73
ISSN
1552-4841
NCID
AA11815089
Content Type
Journal Article
language
英語
Copyright Holders
Wiley-Liss, Inc.
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
biology_general/32