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Title Alternative
Antagonistic activity of L-histidine to the methamphetamine-induced hyperactivity in mice
Author
Senoh, Shin
Abstract
The mechanism by which L-histidine inhibits the methamphetamine (MAP)-induced hyperactivity was examined in mice. L-histidine (1g/kg, i. p.) significantly reduced the locomotor hyperactivity induced by MAP (1mg/kg, i. p.) in either experiment using Open field or Animex apparatus, although L-histidine did not affect the locomotor activity of control mice. L-histidine elevated brain levels of histamine and tele-methylhistamine. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of L-histidine. Metoprine, a histamine-N-methyltransferase inhibitor, increased brain histamine level and suppressed the MAP-induced locomotor hyperactivity. Although L-histidine (1g/kg) markedly changed brain tyrosine levels, this amino acid alone had no significant influence on the monoamine metabolism. It did not modify the change in the monoamine metabolism induced by MAP (1mg/kg), either. The inhibition by L-histidine of the MAP-induced hyperactivity was observed in the mice pretreated with para-chlorphenylalanine or atropine. These results suggest that central histaminergic systems may have an inhibitory influence on the MAP-induced locomotor hyperactivity. However, serotonergic and cholinergic mechanisms seem not to be involved in this phenomenon.
Keywords
methamphetamine
L-histidine
histamine
運動量
Published Date
1990-04
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
347
End Page
356
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/3-4/102_3-4_347/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma