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Title Alternative
Molecular genetic survey of 5 kindreds with kininogen deficiency in Japan 1. Immunoblot analysis of kininogen deficiency
Author
Ishimaru, Eiji
Abstract
Analysis of kininogen molecule status in four Japanese families affected with total kininogen deficiency and one Japanese family with isolated high molecular weight kininogen deficiency was performed using an immuoblotting method with monoclonal antibodies to high molecular weight kininogen (HKG H 12, L 7, L 17). The purified high molecular weight kininogen showed two bands with apparent mot wts of 120, 000 and 105, 000, respectively, and the purified low molecular weight kininogen showed a single band with an apparent mot wt of 60, 000. In normal human plasma, these three bands were also detected. No variant molecule of the kininogens was present in either cases of total kininogen deficiency or isolated high molecular weight kininogen deficiency.
Keywords
high molecular weight kininogen
low molecular weight kininogen
kininogen deficiency
immunoblotting
monoclonal antibody
Published Date
1990-04
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
365
End Page
376
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
http://www.journalarchive.jst.go.jp/japanese/jnlabstract_ja.php?cdjournal=joma1947&cdvol=102&noissue=3-4&startpage=365
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma