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ID 40619
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Title Alternative
The effects of arterial blood halothane or enflurane concentration on the circulatory system
Author
Kosaka, Makoto
Abstract
The effects of halothane (H) or enflurane (E) concentration on the circulatory system were studied in dogs. Two hours of halothane or enflurane anesthesia resulted in a linear dose-dependent decrease in circulatory indices inculding: mean arterial pressure (mAP), heart rate (HR), cardiac index (CI) and left ventricular peak dp/dt/IP (peak dp/dt/IP). Systemic vascular resistance (SVR) did not change during either anesthesias. The correlations between the percent change of circulatory indices and the logarithm of the blood anesthetic concentrations were expressed by correlation coefficients (r): mAP, r=-0.718 (H), and -0.650 (E); HR, r=-0.329 (H), and -0.352 (E); CI, =-0.597 (H), and -0.596 (E); SVR, r=-0.161 (H), and -0.030 (E); peak bp/dt/IP, r=-0.708 (H), and -0.871 (E). Using several indices of anesthetic depth including MAC, MAC-EI and MAC-BAR, the percent change of mAP, CI and peak dp/dt/IP were calculated at the same anesthetic depth using halothane or enflurane. These results indicated that enflurane depressed these circulatory indices more than halothane. These defferences were: mAP, 14.51±1.46%; CI, 8.14±1.86%; peak dp/dt/IP, 7.38±3.95% (mean±SD). These results, indicate that the depression of circulatory indices at the same anesthetic depth could be expressed by numerical values.
Keywords
血中ハロセン濃度
血中エンフルレン濃度
循環動態
Published Date
1990-04
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
391
End Page
404
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/3-4/102_3-4_391/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma