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Title Alternative
Acetylcholine turnover on the experimental epileptic focus of the rat cerebral cortex
Author
Kawakami, Yunosuke
Abstract
The effect of iron ion injection on acetylcholine (ACh) turnover was studied in the cerebral cortex of male Sprague-Dawley rats. Rats were divided into 3 groups: rats of the Fe-group were injected with 500 nmol of Fe(3+) in the left sensorimotor cortex, rats of the HCl-group were injected with HCl-acidified saline (pH 1.8) in the left sensorimotor cortex, and a shamoperated group acted as a control (Sham-group). On both sides of the cortex, the choline acetyltransferase (CAT) activity of the HCI- and Fe-groups decreased 30 min after, increased 6h after, and then decreased 24h after the injection compared with the activity of the Sham-group. A no time was there any difference between the CAT activities of the HCl- and Fe-groups. On both sides of the cortex, the ACh content of the HCl- and Fe-groups decreased transiently 24h after injection, but there was no difference in ACh content between the two groups. In the left cortex of the Fe- and HCl-groups, acetylcholinesterase (AChE) activity, which showed no difference between the two groups, decreased 30 min after injection. These findings suggested that cortical neurons especially AChergic neurons might be irritated by a transient increase in intracranial pressure due to brain edema induced by the injection of acid into the cortex, as no specific effct of Fe(3+)-injection was observed in this study.
Keywords
acetylcholine turnover
head injury
choline acetyltransferase
cholinesterase
brain edema
Published Date
1990-04
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
453
End Page
463
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/3-4/102_3-4_453/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma