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ID 40676
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Title Alternative
Changes in and the significance of serum immunosuppressive substances (ISS) and NK activity in murine cardiac homotransplantation
Author
Kimura, Takanobu
Abstract
Heterotopic homotransplantation of rat hearts was performed and ISS and NK activity levels were determined before and after rejection. The effects of prostaglandin (PGE(2)), cyclosporin A, and indomethacin on the acceptance of transplanted hearts as well as on ISS and NK activity were studied. PGE(2) and PGI(2) significantly extended survival when compared to a control group, while indomethacin decreased survival. ISS peaked 4 days before the rejection of transplanted hearts, suggesting its usefulness as a marker of rejection. Moreover, NK activity was significantly higher around the time of rejection, suggesting the importance of NK cells in this process. Finally, rejection was suppressed by administration of PGE(2).
Keywords
ラット心移植
ISS
NK細胞活性
プロスタグランジン
インドメサシン
Published Date
1990-10
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1083
End Page
1090
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/9-10/102_9-10_1083/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
OAI-PMH Set
岡山大学
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma