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ID 41148
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Title Alternative
Studies on Ascitic Rickettsia of the Tsutsugamushi Disease Infected Guinea Pig Part II Complement Fixation Reaction Using the Ascites of Tsutsugamushi Disease Infected Guinea Pig as Antigen
Author
Mino, Jiro
Abstract
It has been already shown that the tsutsugamushi disease rickettsia obtained from the infected mouse of this disease, that mouse was repeatedly injected small dose of chloramphenicol, is highly capable of inducing the disease to the chlorpromazine treated guinea pig leading to the much production of ascites and the antigenic capacity of this ascites was inferior to that obtained from the infected animal by the original strain of the organism owing to the variation on some properties of the organism by chloramphenicol. The author studied the complement fixation reaction using the original strains, OSEKI's, MITANI's, and HICHITO strains and the strains obtained by variation of these and found some specificity on the antigen. In any case of the test, the ascites was obtained from the organism inoculated guinea pig and used as antigen for complement fixation reaction. From the view of the results, all ascites obtained by inoculation of the original strains showed difinite strain specificity to the corresponding antiserum, but those by the varied strains showed only slight inhibition on hemolysis in any case just like having no strain specificity. Hence, it was confirmed that the occurence of variation on the properties of the tsutsugamushi disease rickettsia by action of chloramphenicol.
Published Date
1959-09-10
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue9-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
6025
End Page
6037
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/9-2/71_9-2_6025/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma