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ID 41232
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Title Alternative
Studies on the Poisoning by Organic Chloride Solvents Part 3. Study on Fujiwara-reaction Positive Substance in the Urine of the Rabbits Administered Teteachloroethylene
Author
Kuwada, Akira
Abstract
After the subcutaneous administration of tetrachloroethylene to rabbits by means of Fujiwara's reaction the author studied Fujiwara-reaction positive substance, the in vivo metabolite excreted in the urine of these animals; and obtained the following resultt. 1. Fujiwara-reaction positive substance in the urine is soluble in water, and in the presence of acid it is soluble in ethylether. The color tones and colorimetric findings of this substance are exactly identical with those of trichloro-aceticacid and likewise Rf in the paper chromatography rather coincides with the latter. 2. A considerable amount of the Fujiwara-reaction positive substance is excreted in the urine on the first day of tetrachloroethylene administration, and reaching its maximum on the second day but decreasing thereafter, the excretion lasts for 7-14 days. 3. In calculating this Fujiwara-reaction positive substance in term of the quantity equivalent to trichloro-acetic acid, its excretion percentage is 1.43-3.08 per cent, showing a parallel relationship between the total Fujiwara-reaction positive substance excreted in the urine and quatity of tetrachloroethylene administered.
Published Date
1959-09-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue10-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
6907
End Page
6916
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/10-2/71_10-2_6907/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma