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Title Alternative
Mechanism of Lymphagogic Action of a Corbicula Extract, with Special Reference to the Liberation of Secondary Active Substance
Author
Takaoka, Tateo
Abstract
A water-soluble, alcohol-insoluble extract was prepared from the viscera of Corbicula japonica Prime. This was found to have a marked lymphagogic action on the thoracic lymph of a dog, and also a special action on the liver circulation, as was found earlier by Yamasaki et al. (Folia pharmacol. japon. 31, 22, 1941) with the extract prepared in a similar manner from Corbicula sandai Reinhardt. The lymphagogic action and actions of elevating portal pressure and of lowering arterial pressure of this extract were all more marked in the case of intraportal injection than by systemic injection. There was a marked tachyphylaxis in all these actions. After intravenous injection of this extract, there was no increase of histamine equivalent in the blood and thoracic lymph sufficient to account for the foregoing lymphagogic action and there was no change in the histamine content of the liver, muscles and the skin. Intraportal injection of adenosine triphosphate also effected an increase of thoracic lymph flow, decrease of its coagulability, and changes in the portal and arterial blood pressure and respiration as in the case of intravenous injection of the corbicula extract. A substance (or substances) exhibiting the maximum absorption at 255-260 mμ was detected in the plasma from the hepatic venous blood immediately after intraportal injection of this extract. These observations suggest that the lymphagogic action of this extract is due to adenosine triphosphate or some related substance liberated from the liver.
Published Date
1957-01-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume69
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1
End Page
16
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/69/1/69_1_1/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma