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ID 48706
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Author
Teraoka, Junichi
Sakoda, Akihiro
Nishiyama, Yuichi
Yamato, Keiko
Monden, Mayuko
Ishimori, Yuu
Nomura, Takaharu
Abstract
We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.
Keywords
radon inhalation
inflammation
carrageenan
edema
antioxidative function
Published Date
2012-04-01
Publication Title
Inflammation
Volume
volume35
Issue
issue2
Publisher
Springer Science+Business Media, LLC
Start Page
713
End Page
722
ISSN
0360-3997
NCID
AA00673765
Content Type
Journal Article
Official Url
http://www.springerlink.com/content/l301166n92348401/
language
英語
Copyright Holders
© Springer Science+Business Media, LLC 2011
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Refereed
True
DOI
PubMed ID
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