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Title Alternative
Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by downregulating Th1 and Th17
Author
Keywords
慢性移植片対宿主病
同種造血幹細胞移植
Th17細胞
Th1細胞
Am80
Note
平成23年度岡山医学会賞(林原賞)受賞論文 (The 2011 Okayama Medical Association Award)
Published Date
2012-12-03
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume124
Issue
issue3
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
197
End Page
201
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
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2) Ferrara JL, Levine JE, Reddy P, Holler E : Graft-versus-host disease. Lancet (2009) 373, 1550-1561.
3) Ferrara JL, Antin JH : The pathophysiology of graft-vs-host disease ; in Thomas' Hematopoietic Cell Transplantation, Blume KG, Forman SJ, Appelbaum FR (eds), Blackwell, Malden (2004) pp353-368.
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5) Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C : A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 6, 1133-1141.
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9) Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR : IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 8, 967-974.
10) Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C : STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem (2007) 282, 9358-9363.
11) Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, et al. : T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2008) 28, 29-39.
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13) Yi T, Zhao D, Lin CL, Zhang C, Chen Y, Todorov I, LeBon T, Kandeel F, Forman S, Zeng D : Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood (2008) 112, 2101-2110.
14) Kappel LW, Goldberg GL, King CG, Suh DY, Smith OM, Ligh C, Holland AM, Grubin J, Mark NM, Liu C, Iwakura Y, Heller G, et al. : IL-17 contributes to CD4-mediated graft-versus-host disease. Blood (2009) 113, 945-952.
15) Carlson MJ, West ML, Coghill JM, Panoskaltsis-Mortari A, Blazar BR, Serody JS : In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease
with severe cutaneous and pulmonary pathologic manifestations. Blood (2009) 113, 1365-1374.
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19) Nagai H, Matsuura S, Bouda K, Takaoka Y, Wang T, Niwa S, Shudo K : Effect of Am-80, a synthetic derivative of retinoid, on experimental arthritis in mice. Pharmacology (1999) 58, 101-112.
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language
日本語
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Copyright (c) 2012 岡山医学会
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joma