このエントリーをはてなブックマークに追加
ID 52866
FullText URL
Author
Yamamoto, Hiroshi
Abstract
The key precursor, N-2-(N,N -dimethylaminomethylene)-6-hydroxymethyl-8-methyl-3-[2-(4-nitrophenyl)ethyl]-7-xanthopterin (16) was efficiently prepared from 2,5-diamino-6-methylamino-3H-pyrimidin-4-one (5) and ethyl 3-(tert-butyldimethylsilyloxy)-2-oxopropionate (12), followed by the protection of the pteridine ring. Glycosylation of 16 with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose (18) in the presence of tin(IV) chloride yielded the corresponding beta-D-ribofuranoside. Successive removal of the protecting groups of the resulting D-ribofuranoside provided asperopterin A (4b).
Keywords
asperopterin
glycosylation
isoxanthopterin
protecting groups
pterin glycoside
Note
“The final publication is available at www.degruyter.com”.
Published Date
2013-06
Publication Title
Pteridines
Volume
volume24
Issue
issue1
Publisher
International Society of Pteridinology
Start Page
3
End Page
6
ISSN
0933-4807
Content Type
Journal Article
language
英語
Copyright Holders
© International Society of Pteridinology
File Version
publisher
Refereed
True
DOI
Web of Sience KeyUT