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ID 53142
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Author
Shoji, Bon
Fujioka, Shin-ichi
Kobashi, Haruhiko
Yasunaka, Tetsuya
Miyake, Yasuhiro
Takaki, Akinobu Kakenhi
Nouso, Kazuhiro
Abstract
For patients with chronic hepatitis due to hepatitis B virus (HBV), factors predicting hepatocellular carcinoma (HCC) other than high levels of HBV-DNA and alanine aminotransferase (ALT) are needed to prevent HCC development, as many patients with chronic HBV infection fulfill these conditions. The purpose of this study was to clarify factors predictive of HCC development for those patients. The study was a systematic cohort analysis of 303 consecutive patients with hepatitis B e-antigen, receiving laparoscopic examination for assessment of liver disease. Laparoscopic, histological, and clinical characteristics were investigated as related to HCC development. HCC occurred in 27 patients during a mean follow-up of 8.0 +/- A 5.0 years, at the age of 37-72 years. Significant associations with HCC development were shown for liver cirrhosis, histological activity grade, reddish markings, and older age. Multivariate analysis revealed that HCC development was strongly associated with older age and male gender (P = 0.002 and P = 0.043, respectively). HCC occurred more frequently in patients of age a parts per thousand yen30 years even with early stage than in patients of age < 30 years (P = 0.031). Severe reddish markings, a laparoscopic finding of widespread parenchymal destruction, were highly associated with HCC development in patients of age a parts per thousand yen30 years at diagnosis (odds ratio = 1.67, P = 0.034), while histological activity grade and ALT level were not (P = 0.075 and P = 0.69, respectively). HCC development is associated with older age, male gender, and liver cirrhosis. Reddish markings, rather than histological activity or ALT level, can be useful to predict HCC for HBV patients of age a parts per thousand yen30 years.
Keywords
Hepatitis B virus
Hepatocellular carcinoma
Laparoscopy
Published Date
2010-11
Publication Title
Journal of Gastroenterology
Volume
volume45
Issue
issue11
Start Page
1172
End Page
1182
ISSN
0944-1174
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/53135
language
英語
Copyright Holders
© Springer 2010
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Refereed
True
DOI
Web of Sience KeyUT