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A primary diffuse large B-cell lymphoma of the liver treated with R-CHOP regimen
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Okada, Hiroshi
Fujii, Soichiro
Watanabe, Kentaro
Shigematu, Terunobu
Miyashita, Katsuhiro
Okazaki, Morihiro
Kobashi, Haruhiko
Yokoyama, Motohiro
 A 78-year-old Japanese man was referred to our hospital after experiencing black feces. No abnormal finding was detected in the endoscopic examination of his stomach and large intestines. Computed tomography (CT) of the abdomen revealed a tumor lesion in the right lobe of the liver. A needle biopsy of the tumor under ultrasound guidance was performed. A pathological examination of the biopsy specimen showed a diffuse proliferation of lymphoma cells, which was compatible with diffuse large B-cell lymphoma (DLBCL). F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT demonstrated increased FDG uptake only in the liver tumor. We made the diagnosis of primary DLBCL of the liver. After six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), the patient achieved complete remission and has maintained remission for 2 years since the diagnosis. The R-CHOP regimen might be effective therapy for primary DLBCL of the liver.
びまん性大細胞型B細胞リンパ腫(diffuse large B-cell lymphoma)
R-CHOP療法(R-CHOP regimen)
症例報告(Case Reports)
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Okayama Medical Association
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Journal Article
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Copyright (c) 2015 岡山医学会
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1) Freeman C, Berg JW, Cutler SJ : Occurrence and prognosis of extranodal lymphomas. Cancer (1972) 29, 252-260.
2) The International Non-Hodgkin's Lymphoma Prognostic Factors Project : A Predictive Model for Aggressive Non-Hodgkin's Lymphoma. N Engl J Med (1993) 329, 987-994.
3) Caccamo D, Pervez NK, Marchevsky A : Primary lymphoma of the liver in the acquired immunodeficiency syndrome. Arch Pathol Lab Med (1986) 110, 553-555.
4) Levy AD : Malignant liver tumors. Clin Liver Dis (2002) 6, 147-164.
5) Apicella PL, Mirowitz SA, Weinreb JC : Extension of vessels through hepatic neoplasms ; MR and CT findings. Radiology (1994) 191, 135-136.
6) Takeuchi N, Naba K : Primary Hepatic Lymphoma is Difficult to Discriminate from a Liver Abscess. Case Rep Gastrointest Med (2014) 2014, 925307.
7) Noronha V, Shafi NQ, Obando JA, Kummar S : Primary non-Hodgkin's lymphoma of the liver. Crit Rev Oncol/Hematol (2005) 53, 199-207.
8) Silvestri F, Pipan C, Barillari G, Zaja F, Fanin R, Infanti L, Russo D, Falasca E, Botta GA, Baccarani M : Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders. Blood (1996) 87, 4296-4301.
9) Avlonitis VS, Lions D : Primary hepatic lymphoma ; a review. Eur J Surg (1999) 165, 725-729.
10) Page RD, Romaguera JE, Osborne B, Medeiros LJ, Rodriguez J, North L, Sanz-Rodriguez C, Cabanillas F : Primary hepatic lymphoma ; favorable outcome after combination chemotherapy. Cancer (2001) 92, 2023-2029.
11) Zentar A Tarchouli M, Elkaoui H, Belhamidi MS, Ratbi MB, Bouchentouf SM, Ali AA, Bounaim A, Sair K : Primary hepatic lymphoma. J Gastrointest Canc (2014) 45, 380-382.
12) Bouliaris K, Christodoulidis G, Koukoulis G, Mamaloudis I, Ioannou M, Bouronikou E, Palassopoulou M, Tepetes K : A primary hepatic lymphoma treated with liver resection and chemotherapy. Case Rep Surg (2014) 2014, 749509.
13) Gomyo H, Kagami Y, Kato H, Kawase T, Ohshiro A, Oyama T, Kamiya Y, Taji H, Nakamura S, Ogura M, Morishima Y : Primary hepatic follicular lymphoma ; a case report and discussion of chemotherapy and favorable outcomes. J Clin Exp Hematop (2007) 47, 73-77.
14) Myoteri D, Dellaportas D, Arkoumani E, Marinis A, Zizi-Sermpetzoglou A : Primary Hepatic Lymphoma ; A Challenging Diagnosis. Case Rep Oncol Med (2014) 2014, 212598.
15) Tammana VS, Begum R, Oneal P, Karpurapu H, Muley A, Yeruva SLH, Dunmore-Griffith J, Mekonen E, Hasan N : A Novel Use of Early Radiation Therapy in the Treatment of Hyperbilirubinemia in a Patient with Primary Hepatic Lymphoma and Chronic Hepatitis C. Case Rep Gastrointest Med (2014) 2014, 724256.
16) Resende V, Oliveira TS, Gomes RT, Laboissière RS, Tavares-Junior WC, de Melo Couto OF : Primary hepatic lymphoma ; A case report. Int J Surg Case Rep (2013) 4, 1165-1168.