岡山大学環境理工学部研究報告 ISSN 2187-6940
Published by Faculty of Environmental Science and Technology, Okayama University

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Statistical threshold model and radiosensitivity on binary data of radiation related cataract and epilation

Otake, Masanori
Tanaka, Yutaka
Tomita, Makoto
Abstract
An analytic approach that provides explicit estimates of risk on cataract and epilation data is evaluated by reasonableness of conceivable relative risk models regarding a simple, odds, logistic or Gompertz regression method, assuming a binomial distribution. In these analyses, we apply relative risk models with two thresholds between epilators and nonepilators from a highly characteristic lesion of which radiation cataract does not occur around 2 gray for a single acute exposure. The risk models are fitted to the data assuming 10 as a constant relative biological effectiveness of neutron. The likelihood of observing the entire data set in these models fitted is evaluated by an individual binary-response array. Estimation of a threshold with or without severe epilation and the 100(1-α )% confidence limits are derived from the maximum likelihood approach. The relative risk model with two thresholds can be expressed as a formula with structure of Backgroun × RR, where RR includes threshold models with or without epilation. The radiosensitivity of ionizing radiation to cataracts has been examined for the relationship between epilators and nonepilators.
Keywords
radiation cataract
threshold model
profile approach
risk model
radiosensitivity
ISSN
1341-9099
NCID
AN10529213