岡山大学環境理工学部研究報告 ISSN 2187-6940
Published by Faculty of Environmental Science and Technology, Okayama University

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ゲルパ-ミエーションクロマトグラフィ用ゲル充填剤としての単分散親水性高分子ミクロスフィアの開発

Yoshizawa, Hidekazu
Ikeda, Satoshi
Kitamura, Yoshiro
Hasegawa, Masadumi
Moriyama, Hiroyuki
Kawano, Yoshinobu
Hatate, Yasuo
Abstract
Monodispersed porous polymer microspheres having diameter of ca. 50 μm were successfully prepared by suspension polymerization of styrene, polyoxyethylene methacrylate and ethylenegycol dimethacrylate. Monodispersed O/W emulsion was firstly made by SPG membrane emulsification technique, following droplets-swelling method of monodispersed seed emulsion by the addition of secondary emulsion. The effect of solvent used in suspension polymerization on porous structure of prepared polymer microspheres was investigated in this paper by identification with scanning electron microscopy, porosimeter and the performance in gel permeation chromatography. It was found that benzene, 1-butanol and butyl acetate worked as poor solvent for polymer prepared in this study and that polymer microspheres prepared with these solvents had larger pores. Gel permeation chromatography measurements indicates that polystyrene having molecular weight smaller than 50,000-100,000 can be clearly separated by using gel columns packed with polymer microspheres prepared with poor solvents.
Keywords
polymer microsphere
monodispersed emulsion
swelling method
hydrophilic polymer
gel permeation chromatography
size-exclusive separation
ISSN
1341-9099
NCID
AN10529213