岡山大学環境理工学部研究報告 ISSN 2187-6940
Published by Faculty of Environmental Science and Technology, Okayama University

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制癌剤を内包したポリ乳酸微粒子製剤の調製とその徐放挙動

Nishino, Satoru
Yoshizawa, Hidekazu
Natsugoe, Shoji
Aiko, Takashi
Hatate, Yasuo
Kitamura, Yoshiro
Abstract
Recently, many antitumor agents developed. Irinotecan hycrochloride (CPT) has a great side effect even though it is well effective against the cancer. Drug delivery system (DDS) medicine indicates that the release rate of medicine is constant for a long time. Therefore, in order to materialize the general idea of DDS, we applied microencapsulation technique to prepare biodegradable polymer microspheres (MS) enclosing antitumor drug having no side effect. Polylactide microparticles enclosing antitumor agent were prepared by solvent evaporation method under various operation conditions. The effects of operation parameter on release rate of drug and morphology of microparticles were studied.
Keywords
DDS
microparticle
polylactide
antitumor agent
solvent evaporation
DSC
ISSN
1341-9099
NCID
AN10529213