Journal of Okayama Medical Association
Published by Okayama Medical Association

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高血圧自然発症ラットにおける脈絡膜血管病変の組織学的研究 第2報 晩期高血圧自然発症ラットにおける脈絡膜と網膜色素上皮細胞の変化について

Sakaguchi, Noriko
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Abstract
The pathological changes in the choroid and the retinal pigment epithelium in spontaneously hypertensive rats (SHR) aged 42-117 weeks were observed by transmission electron microscopy. Wistar Kyoto rats (WKY) were also studied as normotensive controls. Some of the endothelial cells of the choroidal arterioles and capillaries were degenerated. Focal cytoplasmic necrosis of the arteriolar smooth muscle cells was seen. The choroid showed severe sclerotic changes, and the retinal pigment epithelium was degeneated with dilated basal infoldings and intracellular vacuoles. Long-term hypertension causes degeneration of the outer retinal layer due to the obstructive changes in the choroidal vasculature.
Keywords
高血圧
脈絡膜
網膜
病理
Note
原著
ISSN
00301558
NCID
AN00032489