Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

ニガウリ抽出物の血糖降下作用に関する文献的考察

Mankura, Mitsumasa
Noda, Yasuko
Mori, Akitane
Thumnail 124_15.pdf 4.62 MB
Abstract
Diabetes mellitus (DM) represents a global health and economical problem. Many patients with DM in Asia, South America, India and East Africa have traditionally used the water extract of unripe fruits of Momordica charantia (bitter melon) as some form of complementary and alternative medicine. Studies of laboratory animals have shown the beneficial blood-glucose lowering and anti-diabetic effects of this remedy. Some oral components that bring lower blood glucose level have been isolated : charantin (sterol glycosides), charantin (polypeptide) and cucurbine-type triterpenes. Part of their actions are related to AMP-activated kinase and repression of the oxidative stress that is increased in DM. Most clinical reports are not fully convincing due to the lack of randomized control studies. The present article reviews the pharmacological and clinical effects of bitter melon with special emphasis on the anti-diabetic effects, and some effects that would require caution in the context of human trials.
Keywords
ニガウリ (bitter melon)
Momordica charantia
糖尿病 (diabetes mellitus)
酸化ストレス (oxidative stress)
Note
総説(Review)
ISSN
0030-1558
NCID
AN00032489
DOI