The glycolysis and tissue respiration in the specimen of the brain of chronic cerebral local anaphylactic rabbits showed rather lower value than those in normal group. But the glutamic acid, when added to the specimen accelerated the glycolysis and tissue respiration so, that they showed no significant difference from those in normal group. From these facts, it is considered that in the brain of chronic cerebral local anaphylactic rabbits gltamic substances are decresed or short. But supply of glutamic acid could not make better the mean value than normal. Even if the defect of glutamic acid is supplemented, however, the glycolysis and the tissue respiration of the anaphylactic rabbits never excee the normal limit.