Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

制癌剤の担癌体に及ぼす影響に関する研究 第4編 担癌体に対する制癌剤投与時の副作用防止に関する実験的研究

Kameyama, Hideyuki
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As mentioned above, the significant inhibition of the development of the neoplastic tissue and the improvement of the reticuloendothelial function has been noted with the administration of the Mitomycin C 500 mcg/kg daily for 4 days. In the Mitomycin C treatment, the effectiveness of the various drugs; pantothenic acid, essential amino acid, Vitamine B(12), Vitamine K, to the endothelial system is studied, using serum iron colloid by labelled (59)Fe as an indicator. The phagocytosis of the reticuloendotherial system and the Hb incorporation of the (59)Fe are accelerated in all cases with these drugs, especially in the pantothenic acid and Vitamine B(12). In the combined therapy of the Mitomycin C and these drugs, the distribution of (59)Fe is decreased in the liver and neoplastic tissue and increased in the spleen, kidney, bone and muscle. The development of the neoplastic tissue is furthermore inhibitted in these combined treatments, especially in the pantothenic acid.