Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

四塩化炭素肝障害ラットにおける1-(2-Tetrahydrofuryl)-5-fluorouracilの血中消失速度定数に及ぼす還元型グルタチオンとビタミンEの影響

Hobara, Norio
Watanabe, Akiharu
Nagashima, Hideo
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Abstract
The pharmacokinetics of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) were analysed by measuring its disappearance rate (K) from the circulating blood using a high-pressure liquid chromatographic technique. An increase in the disappearance rate of FT was observed by treatment with reduced glutathione (GSH)- or tocopheryl nicotinate-treated rats. The clearance rates of FT from the circulating blood in carbon tetrachloride (CCl(4))-injured rats were much smaller than those in untreated rats. The unresponsiveness of K values to treatment with GSH or tocopheryl nicotinate was seen in liver-injured rats.
Keywords
四塩化炭素肝障害
FT
ビタミンE
還元型グルタチオン
血中消失速度定数
ISSN
0030-1558
NCID
AN00032489