Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Basophil response to antigen and anti-IgE 3. Ca(2+) influx and histamine release

Tanizaki, Yoshiro
Kitani, Hikaru
Okazaki, Morihiro
Mifune, Takashi
Kimura, Ikuro
Abstract
The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE.
Keywords
Ca(2+) influx (Ca2+流入)
histamine release (ヒスタミン遊離)
house dust (ハウスダスト)
Candida albicans (カンジダ)
anti-lgE (抗ヒトIgE)
ISSN
0913-3771
NCID
AN10430852