Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

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岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Decrease in histamine release from bronchoalveolarcells with aging in patients with atopic asthma sensitive to house dust mite

Tanizaki, Yoshiro
Mifune, Takashi
Kajimoto, Kazuhiro
Hosaki, Yasuhiro
Yokota, Satoshi
Ochi, Koji
Harada, Hideo
Taketa, Kazuhisa
Abstract
Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/mℓ) than in older patients (40+ years) (0.39±0.24×10(2)/mℓ) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging.
Keywords
Bronchial asthma
House dust allergy
Histamine release
Bronchoalveolar cells
ISSN
0918-7839
NCID
AN10430852