Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

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岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Oncogenes and tumor suppressor genes in pancreatic cancer

Ochi, Koji
Matsumura, Naoki
Ichimura, Mitsuko
Harada, Hideo
Hasuoka, Hideaki
Yokoyama, Motohiro
Tsurumi, Tetsuya
Tanizaki, Yoshiro
Abstract
Recent advances in molecular biology have revealed that a number of oncogenes (K-ras, erbB-2, and Met) and tumor suppressor genes (p53, p16, APC, and DCC) contribute to the development of pancreatic cancer. This paper reviewed the present knowledge of oncogenes and tumor suppressor genes relevant to pancreatic cancer. Further studies on molecular alterations in pancreatic cancer may lead to a better understanding of tumor biology, offering a possibility of development of new diagnostic and therapeutic approaches in the future.
Keywords
Pancreatic cancer
oncogene
tumor suppressor gene
genetic mutation
ISSN
0918-7839
NCID
AN10430852