Scientific Reports of the Faculty of Agriculture, Okayama University
Published by the Faculty of Agriculture, Okayama University
ONLINE ISSN : 2186-7755

抗リーシュマニア原虫活性物質Ancistrocladinium AとBの合成研究

Kiyota, Hiromasa Graduate School of Environmental and Life Science, Okayama University
Saito, Akihito Graduate School of Agricultural Science, Tohoku University
Takai, Momoko Graduate School of Agricultural Science, Tohoku University
Kuwahara, Shigefumi Graduate School of Agricultural Science, Tohoku University
Abstract
Synthetic studies of ancistrocladinium A and B, antileishmanial compounds isolated from a Congolese Ancistrocladus sp., are described. Buchwald‒Hartwig coupling reaction between the dihydroisoquinoline and the naphthyl triflate failed. The main framework of ancistrocladinium A was constructed by 1,2‒addition of the amine to the naphthoquinone in the presence of celium trichloride as a catalyst. On the other hand, 1,4‒addition of the amine to the naphthoquinone proceeded without catalyst to form the framework of B. These products will be valuable leads for antileishmanial agents.
Keywords
ancistrocladinium A and B
synthetic studies
leishmania, Ancistrocladus
isoquinoline
Note
原著論文 (Original paper)
ISSN
2186-7755