Scientific Reports of the Faculty of Agriculture, Okayama University
Published by the Faculty of Agriculture, Okayama University
ONLINE ISSN : 2186-7755

イソチオシアネートによるがんの化学予防の可能性

Abstract
A promising group of compounds that have a chemopreventive property are isothiocyanates (ITCs). ITCs have been shown to induce apoptosi in various cancer cell lines and experimental rodents. Multiple signaltransduction pathways as well as apoptosis intermediates have been also posturalted. We recently clarified the moleculae mechanism underlying the relationship between cell cycle arrest ad apoptosis induced by benzyl isothiocyanate(BITC), a major ITC compound isolated from papaya. The exposure of cells to BITC resulted in the inhibition of the G2/M progression that coincided with not only hte up-regulated expression of the G2/M cell cycle arrest-regulating genes but also the apoptosis induction. Conversely, treatment with an excessive concentration of BITC resulted in an abortive apoptotic pathway without DNA ladder formation. This commentary will review the biological impact of cell death induction by BITC as well as other ITCs and the involved signal transduction pathways.
Keywords
isothiocyanates
cancer chemoprevention
apoptosis
cell cycle arrest
necrosis
ISSN
0474-0254 
NCID
AN00033029
NAID