start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=2
article-no=
start-page=431
end-page=446
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=19570228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Epidemiologic and Symptomatologic Observations on the Gastric Cancer Patients (Hospitalized Patients, 1945-1956 and Outpatients, 1954-1955)
kn-title=胃癌患者の疫学的並びに症候的観察―昭和20～31年の入院患者並びに昭和29, 30年の外来患者について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Conceding that a great progress of cancer researches is opening up a new phase in the treatment of cancers and realizing an early operation is at the present a sole approach to the gastric-cancer therapy, an early diagnosis seems to be the most important, daily clinical problem we have to face. In view of this we have attempted to grasp the true nature of gastric-cancer patients by a series of epidemiologic and symptomatologic observations statistically on the hospitalized patients during the past 12 years, and outpatients for the past 2 years of our clinic. From our observations we find that the most likely ages of the onset of cancers range from 50 to 60, and that the gastric cancer developing at an early age is found more predominantlyin female. Moreover, in the farm districts, the proportion of female patients far surpasses that of any other occupation. Of all the cancer cases treated during the 12-year periods, the gastric cancer occupied 45 per cent. Of all the outpatients during the two-year periods, 27.8 per cent proved to be suffering from digestive organs; and the gastric cancer cases occupied 5.7 per cent of the latter. Now, it is impossible, simply by its symptoms, to differentiate the gastric cancer from such diseases as the gastric and the duodenal ulcers, and gastritis; as the symptom and chief complaint of the patients at its onset are epigastric pain, the foremost, followed by feeling of full and tension in the epigastrium, and eructation and heart burn, and since all of these have practically no distinguishable difference from those of the latter. Of the total patients, the cases impossible of operation reached as high as 39 per cent while those being operated on but ending only in laparotomy proved to be 15 per cent, and the ones on whom the gastric resection had proved a success were merely 8.8 per cent. It is, moreover, interesting to note that despite as high as 75.8 per cent of the cases having palpable abdominal tumors at the time of admission, the ones whose Virchow's gland and other lymphatic glands had been palpable were extremely little: no more than 0.6 per cent. The occult blood reaction of stool was positive in 71 per cent, and 18 per cent of gastric cancer patients were of either normal or hyper acidity; and 61 per cent of the total had abnormal defecation (constipation, diarrhea, etc.). As for complications, helminthiasis is predominant (30%). This fact is worthy of an attention, for symptoms resulting from helminth's attacks often obscure those of gastric cancer. Reviewing the statistical data so far mentioned, we realize keenly how little early diagnosis of gastric cancer is being carried out and how difficult it is to carry this out; at the same time we have learned, on the other hand, how essential and beneficial it is to grasp epidemiologic and symptomatologic problems for its diagnosis.
en-copyright=
kn-copyright=

en-aut-name=UeharaHideo
en-aut-sei=Uehara
en-aut-mei=Hideo
kn-aut-name=上原偉男
kn-aut-sei=上原
kn-aut-mei=偉男
aut-affil-num=1
ORCID=

en-aut-name=OkuhashiAtsumu
en-aut-sei=Okuhashi
en-aut-mei=Atsumu
kn-aut-name=奥橋褒
kn-aut-sei=奥橋
kn-aut-mei=褒
aut-affil-num=2
ORCID=

en-aut-name=MoritaniHideo
en-aut-sei=Moritani
en-aut-mei=Hideo
kn-aut-name=森谷秀男
kn-aut-sei=森谷
kn-aut-mei=秀男
aut-affil-num=3
ORCID=

en-aut-name=HattoriSusumu
en-aut-sei=Hattori
en-aut-mei=Susumu
kn-aut-name=服部進
kn-aut-sei=服部
kn-aut-mei=進
aut-affil-num=4
ORCID=

en-aut-name=UetsukaKaoru
en-aut-sei=Uetsuka
en-aut-mei=Kaoru
kn-aut-name=上塚香
kn-aut-sei=上塚
kn-aut-mei=香
aut-affil-num=5
ORCID=

en-aut-name=SanadaHiroshi
en-aut-sei=Sanada
en-aut-mei=Hiroshi
kn-aut-name=真田浩
kn-aut-sei=真田
kn-aut-mei=浩
aut-affil-num=6
ORCID=

en-aut-name=MotokuraKiyoshi
en-aut-sei=Motokura
en-aut-mei=Kiyoshi
kn-aut-name=本倉潔
kn-aut-sei=本倉
kn-aut-mei=潔
aut-affil-num=7
ORCID=

en-aut-name=HayashiKazuo
en-aut-sei=Hayashi
en-aut-mei=Kazuo
kn-aut-name=林和雄
kn-aut-sei=林
kn-aut-mei=和雄
aut-affil-num=8
ORCID=

en-aut-name=MiyaiMonziro
en-aut-sei=Miyai
en-aut-mei=Monziro
kn-aut-name=宮井絞治郎
kn-aut-sei=宮井
kn-aut-mei=絞治郎
aut-affil-num=9
ORCID=

en-aut-name=NishiuchiMichio
en-aut-sei=Nishiuchi
en-aut-mei=Michio
kn-aut-name=西内道雄
kn-aut-sei=西内
kn-aut-mei=道雄
aut-affil-num=10
ORCID=

en-aut-name=MatsuyamaTsuneo
en-aut-sei=Matsuyama
en-aut-mei=Tsuneo
kn-aut-name=松山恒男
kn-aut-sei=松山
kn-aut-mei=恒男
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部平木内科教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4-2
article-no=
start-page=1937
end-page=1948
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Iron Metabolism in Hookworm Disease by means of Radioactve Iron (Fe(59)) Administration Part 1. The Iron Metabolism in Dogs with Hookworm Disease
kn-title=放射性鉄による鉤虫症の鉄代謝に関する研究 第1編 鉤虫犬の鉄代謝について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using dogs such as ones spontaneously infected with hookworms, ones dewormed of these hookworms, those experimentally infected with hookworms showing marked intestinal hemorrhage as well as normal dogs (the control), and orally administering them radioactive iron, Fe(59), the author determined the radioactive iron in erythrocytes and plasm periodically. Then 48 hours later perfusion is given and fractionating the visceral iron by Yoneyama-Konno's method, the iron contents and Fe(59) are estimated. As the results, it has been found that the iron-absorption rate is lowest in the dogs spontaneously infected with hookworms, followed in an ascending order of normal dogs and dewormed dogs, and highest in the dogs with experimental hookworm disease. As for the distribution of Fe(59) absorbed, in the spontaneously infected dogs it is distributed mostly in the liver, spleen and bone marrow, demonstrating an extremely low portion of it taken into erythrocytes. In the dewormed dogs, on the contrary, the major portion of the absorbed Fe(59) is taken up by erythrocytes and it is sparsely distributed in the liver, spleen and bone marrow, and this tendency is still more marked in the dogs with experimental hookworm disease, Furthermore, the iron contents of various organs in the dogs spontaneously infected with hookworms, though slightly less than in the normal, are greater than those found in the dewormed dogs, proving a marked decrease in the dogs with experimental hookworm disease. From these data it is assumed that there is a definite impediment to the absorption and mobilization of iron in hookworm disease and that such an impediment together with hemorrhage induce anemia.
en-copyright=
kn-copyright=

en-aut-name=UetsukaKaoru
en-aut-sei=Uetsuka
en-aut-mei=Kaoru
kn-aut-name=上塚香
kn-aut-sei=上塚
kn-aut-mei=香
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4-2
article-no=
start-page=1949
end-page=1958
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Iron Metabolism in Hookworm Disease by means of Radioactive Iron (Fe(59)) Administration Part 2. Effects of the Injection of Hookworm Emulsion on the Iron Metabolism
kn-title=放射性鉄による鉤虫症の鉄代謝に関する研究 第2編 鉤虫乳剤注射の鉄代謝に及ぼす影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=After the oral administration of radioactive iron, Fe(59), to the rabbits injected with emulsion of hookworms from human or dogs and to normal rabbits (control), the author investigated the effects of toxin of the hookworm body on the iron metabolism. As the results the rabbits injected with hookworm emulsion show the lower rate of absorption by the digestive tract and up-take of the absorbed Fe(59) to erythrocytes when compared with the control, and Fe(59) tends to be distributed more in the liver, spleen and bone marrow. At the same time the iron contents in organs show a tendency of an increase as compared with the control. From these findings it appears that toxin in the body of hookworm plays an important role in the disturbances of the absorption and mobilization of iron. In addition, the author conducted similar experiments on the rabbits with chronic anemia by blood depletion and on the rabbits with benzol anemia and compared their results.
en-copyright=
kn-copyright=

en-aut-name=UetsukaKaoru
en-aut-sei=Uetsuka
en-aut-mei=Kaoru
kn-aut-name=上塚香
kn-aut-sei=上塚
kn-aut-mei=香
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4-2
article-no=
start-page=1959
end-page=1968
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Iron Metabolism in Hookworm Disease by means of Radioactive Iron (Fe(59)) Administration Part 3. Effects of the Injection of Hookworm Disease Sera upon the Iron Metabolism
kn-title=放射性鉄による鉤虫症の鉄代謝に関する研究 第3編 鉤虫症血清注射の鉄代謝に及ぼす影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By oral administration of radioactive iron, Fe(59), to the rabbits injected with the serum of patient with hookworm disease or with the serum of dogs with hookworms as well as to the rebbits (the control) injected with sera of normal person or of normal dogs, the author studied the effects of toxin in the sera of hookworm disease upon the iron metabolism. As the results it has been found that the rate of iron absorption in the rabbits injected with the sera of hookworm disease is lower than that in the control, and in these test animals the rate of iron being taken into erythrocytes is also low. Fe(59) tends to be distributed more in the liver and spleen, at the same time the iron contents in organs show a tendency of increasing. This tendency is exactly identical with the results observed in the rabbits injected with hookworm emulsion (Part 2), proving that the toxin in the serum of hookworm disease is also involved in the interferance with the absorption and mobilization of iron as the case of toxin of the body of hookworm.
en-copyright=
kn-copyright=

en-aut-name=UetsukaKaoru
en-aut-sei=Uetsuka
en-aut-mei=Kaoru
kn-aut-name=上塚香
kn-aut-sei=上塚
kn-aut-mei=香
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END