このエントリーをはてなブックマークに追加
ID 19387
Eprint ID
19387
FullText URL
Thumnail 71_1937.pdf 1.77 MB
Title Alternative
Studies on the Iron Metabolism in Hookworm Disease by means of Radioactve Iron (Fe(59)) Administration Part 1. The Iron Metabolism in Dogs with Hookworm Disease
Author
Uetsuka, Kaoru
Abstract
Using dogs such as ones spontaneously infected with hookworms, ones dewormed of these hookworms, those experimentally infected with hookworms showing marked intestinal hemorrhage as well as normal dogs (the control), and orally administering them radioactive iron, Fe(59), the author determined the radioactive iron in erythrocytes and plasm periodically. Then 48 hours later perfusion is given and fractionating the visceral iron by Yoneyama-Konno's method, the iron contents and Fe(59) are estimated. As the results, it has been found that the iron-absorption rate is lowest in the dogs spontaneously infected with hookworms, followed in an ascending order of normal dogs and dewormed dogs, and highest in the dogs with experimental hookworm disease. As for the distribution of Fe(59) absorbed, in the spontaneously infected dogs it is distributed mostly in the liver, spleen and bone marrow, demonstrating an extremely low portion of it taken into erythrocytes. In the dewormed dogs, on the contrary, the major portion of the absorbed Fe(59) is taken up by erythrocytes and it is sparsely distributed in the liver, spleen and bone marrow, and this tendency is still more marked in the dogs with experimental hookworm disease, Furthermore, the iron contents of various organs in the dogs spontaneously infected with hookworms, though slightly less than in the normal, are greater than those found in the dewormed dogs, proving a marked decrease in the dogs with experimental hookworm disease. From these data it is assumed that there is a definite impediment to the absorption and mobilization of iron in hookworm disease and that such an impediment together with hemorrhage induce anemia.
Published Date
1959-04-05
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue4-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1937
End Page
1948
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/4-2/71_4-2_1937/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma