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ID 13697
Eprint ID
13697
FullText URL
Thumnail 108_97.pdf 482 KB
Title Alternative
Effect of granulocyte colony-stimulating factor (G-CSF) on allogeneic immune responses
Author
Ueyama, Satoshi
Abstract
The administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) increased weight and cellularity of the spleen, leukocyte and granulocyte count of the peripheral blood in a dose- and duration-dependent fashion in mice. When spleen cells as well as serum from mice treated with intraperitoneal injection of 200μg/㎏ of rhG-CSF daily for 7 days were added to an allogeneic mixed lymphocyte reaction (MLR) culture, MLR was significantly suppressed nonspecifically and in a dose-dependent fashion. MLR was also suppressed by adding supernatant of spleen cells using transwells, indicating that suppression was mediated by soluble factor (s) secreted from the spleen cells. The producer cells of the inhibiting factor were found in more mature granulocytes with a high density in the spleen. These results suggested that the proliferated granulocytes induced by G-CSF produced and released factor (s) that suppress allogeneic immune responses.
Keywords
顆粒球コロニー刺激因子(granulocyte colony-stimulating factor ; G-CSF)
同種免疫応答
免疫抑制
リンパ球混合反応
Note
原著
Published Date
1996-06-29
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume108
Issue
issue3-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
97
End Page
105
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_97/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma