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ID 46944
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Author
Ishimoto, Hidekazu
Shibata, Mari
Myojin, Yuki
Tai, Akihiro
Abstract
Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.
Keywords
Ellagitannin
Urolithin A
Antioxidant activity
Anti-inflammatory activity
Published Date
2011-10-01
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
volume21
Issue
issue19
Publisher
Pergamon-Elsevier Science Ltd.
Start Page
5901
End Page
5904
ISSN
0960-894X
NCID
AA1079577X
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2011 Elsevier Ltd. All rights reserved.
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Refereed
True
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