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ID 32167
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Author
Okazaki, Morihiro
Kitani, Hikaru
Mifune, Takashi
Mitsunobu, Fumihiro Kaken ID researchmap
Asaumi, Noboru
Tanizaki, Yoshiro
Harada, Hideo
Kimura, Ikuro
Abstract

Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.

Keywords
house dust mite
bronchial asthma
hyposensitization
specific IgG4
Amo Type
Article
Published Date
1991-08
Publication Title
Acta Medica Okayama
Volume
volume45
Issue
issue4
Publisher
Okayama University Medical School
Start Page
267
End Page
273
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT