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ID 48709
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Author
Kojima, Shuji
Tanizaki, Yoshiro
Abstract
To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.
Keywords
Radon hot spring
Misasa
Cancer-related mortality rate
p53 protein level
Superoxide dismutase activity
Published Date
2005-04-01
Publication Title
Journal of Radiation Research
Volume
volume46
Issue
issue1
Publisher
Journal of Radiation Research Editorial Committee
Start Page
21
End Page
24
ISSN
0449-3060
NCID
AA00705792
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/jrr/46/1/46_1_21/_article
language
英語
Copyright Holders
Copyright © 2005 by Journal of Radiation Research Editorial Committee
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Refereed
True
DOI
PubMed ID
Web of Sience KeyUT