JaLCDOI 10.18926/15275
Title Alternative Cutaneous sarcoidosis : Clinical features and management
FullText URL 009_1_049_057.pdf
Author Nakata, Yasunari| Kataoka, Mikio| Hiramatsu, Junichi| Okazaki, Kazunori| Harada, Mine|
Abstract 1976年から1996年に岡山大学第2内科を受診したサルコイドーシス255例のうち,65例(71病変)の皮膚サルコイドーシス(皮膚サ症)について,臨床経過,臨床検査成績,胸部病変との関連,予後について検討した。皮膚サ症患者の年齢は18歳から77歳で中央値は51歳であった。女性例が42例(65%)と多 く,特に50歳代女性に43%と最も高率であった。皮膚病型では結節型33例,皮下型16例,び慢浸潤型3例,局面型6例,結節性紅斑様皮疹3例,苔癬様型1例,瘢痕浸潤9例であった。皮膚サ症では非皮膚サ症に比して気管支肺胞洗浄液中リンパ球の低率が見られたが,その他の臨床成績に差は認められなかった。皮膚病型別に検討すると,局面型,び慢浸潤型では気管支肺胞洗浄液中リンパ球CD4/CD8比は高く,3年後の皮膚および肺病変の残存率は高かった。一方皮下型ではCD4/CD8比は低く皮膚,肺病変の残存率も低かった。
Abstract Alternative Of 255 patients with clinical and histologic evidence of sarcoidosis, 65 (25percent) presented with various cutaneous manifestations of the disease. Cutaneous sarcoid patients were 42 women and 23 men ranging from 18 to 77 years in age. The skin lesions have included nodular infiltration in 33 patients, subcutaneous tumor in 16 patients, lupus pernio in 3, annual plaques in 6, erythema nodosum-like eruption in 3, lichinoid in 1, and scars in 9. There was no correlation between the presence of cutaneous lesions and chest radiolographic stages, abnormal pulmonary gallium uptake, cell differenciations of bronchoalveolar lavages and serum angiotensin converting enzyme activities. Forty-six patients followed for at least 3 years to determine the course of the disease. Subcutaneous tumors tended to heal within 3 years, while lupus pernio and plaque lesions were likely to have a protracted course.
Keywords サルコイドーシス (sarcoidosis) 皮膚 (skin) 臨床経過 (clinical-features) 予後 (prognosis)
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1998-09-30
Volume volume9
Issue issue1
Start Page 49
End Page 57
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002307751
JaLCDOI 10.18926/15159
Title Alternative Effects of salbutamol and disodium cromoglycate on Specific Airway Resistance (sRaw) and Specific Conductance (sGaw) in Bronchial asthma and Rheunmatoid arthritis.
FullText URL 065_087_095.pdf
Author Yokota, Satoshi| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Takata, Itiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract サルブタモールまたはdisodium cromoglycate(クロモリン)吸入液を,気管支喘息(以下BA)6例,慢性関節リウマチ(以下RA)7例,正常対照5例に吸入させ,吸入前および吸入後約30分に,気道抵抗(sRaw)と気道コンダクタンス(sGaw)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, made in U.S.A.)を用いて測定した。吸入前の値をsGawで比較すると,BAはRAや正常対照に比べ有意に閉塞の程度が強く,RAと正常対照の間では有意な差はなかった。サルブタモール吸入の場合,BAでは吸入後にsRawおよびsGawの有意な改善(P<0.01)がみられ,それらの改善率(%)は,RAや正常対照と比べて有意に高く(P<0.01),RAと正常対照の間では改善率の有意な差は認めなかった。クロモリン吸入の場合,いずれの群においても,sRawおよびsGawの吸入後の変化に有意差はみられなかったが,BAにおいて,sRawの改善率(%)はRAと正常対照に対して,またsGawの改善率(%)は正常対照に対して有意に高く(P<0.05),RAと正常対照の間では,sRaw,sGaw共に改善率(%)の明らかな差はみられなかった。
Abstract Alternative We examined effects of salbutamol sulfate and disodium cromoglycate (cromolyn) on specific airway resistance (sRaw) and specific conductance (sGaw) in 6 patients with bronchial asthma (BA), 7 patients with rheumatoid arthritis (RA), and 5 subjects of controls, using a constant volume, whole body plethysmograph (Sensor Medics Corporation, Anaheim, California, U.S.A.). The results before and 30 minutes after inhalation of agents were compared to evaluate their effects on sRaw and sGaw. Before inhalation, the sGaw of BA was significantly lower than that of RA or controls, and there was no difference between that of RA and normal controls. The sGaw and sRaw in BA were significantly improved (P<0.01) after inhalation of salbutamol and those improvement after inhalation were significantly higher (P<0.01) in BA than those in RA or controls, however there was no difference between those of RA and controls. Although there was no sigificant change of sGaw and sRaw in all groups between before and after inhalation of cromolyn, the improvement of sRaw after inhalation was significantly higher in BA than in RA or controls (P<0.05), and that of sGaw was significantly higher in BA than in controls (P<0.05).
Keywords 気道抵抗 (sRaw) 気道コンダクタンス (sGaw) 気管支喘息 (bronchial asthma) 慢性関節リウマチ (rheumatoid arthritis) 気管支拡張作用 (the effect of bronchodialation)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 87
End Page 95
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307239
JaLCDOI 10.18926/15154
Title Alternative 気管支喘息における血清免疫グロブリン値,末梢血リンパ球数と気管支肺胞洗浄液中の細胞成分との関連
FullText URL 065_055_061.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine|
Abstract Changes in airway inflammation by glucocorticoids were examined in 26 patients with bronchial asthma, divided into two age groups ; 20-59 and 60+ years, in relation to serum immunoglobulin levels and peripheral lymphocyte count. 1. The levels of IgG, IgA and IgM were significantly lower in patients with steroid-dependent intractable asthma (SDIA) of age over 60 years than in those with non-SDIA of the same age group. In patients between the ages of 20 and 59, only serum IgG level was significantly lower in SDIA than in non-SDIA patients. 2. Peripheral lymphocyte count was significantly decreased in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. 3. Number of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly lower and number of BAL neutrophils was significantly higher in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. These results suggest that levels of IgG, IgA and IgM, and peripheral lymphocyte count were significantly suppressed in SDIA patients of age over 60, accompanied with decrease of BAL lymphocytes and increase of BAL neutrophils.
Abstract Alternative 気管支喘息26例(ステロイド依存性重症難治性喘息,SDIA 13例,非SDIA 13例)を対象に,血清免疫グロブリン,IgG,IgAおよびIgM値,および末梢血リンパ球数との関連のもとに,副腎皮質ホルモン長期投与による気道炎症細胞の出現頻度の変化について検討を加えた。なお,年齢による影響を観察する目的で,SDIAおよび非SDIA各13例を,20-59才と60才以上の2群に分けて,それ ぞれのグループの特徴について検討した。1.血清IgG,IgAおよびIgM値は,60才以上の症例において,いずれも非SDIA症例に比べ,SDIA症例で有意に低い値を示した。一方,20-59才の症例群においては,IgG値のみSDIA症例で有意の低下傾向が見られた。2.末梢血リンパ球数は,60才以上の症例では,SDIA症例で,非SDIA症例に比べ有意の低値を示したが,20-59才の症例では両群間に有意の差は見られなかった。3.気管支肺胞洗浄(BAL)液中のリンパ球数 は,60才以上のSDIA症例で,非SDIA症例に比べ有意に少なく,また同時にこれらの症例ではBAL液中好中球が有意に多い傾向が観察された。しかし,20-59才の症例群では,SDIAと非SDIAの間にいずれも有意の差は見られなかっ た。これらの結果より,60才以上の症例では,20-59才の症例群に比べ,副腎皮質ホルモンの長期投与により,血清IgG,IgAおよびIgM値,末梢血リンパ球数の減少とともに,BAL液中のリンパ球減少,好中球増加をきたしやすいことが明らかにされた。
Keywords serum immunoglobulin levels (血清免疫グロブリン値) lymphocytes (リンパ球) neutrophils (好中球) bronchial asthma (気管支喘息) glucocorticoids (副腎皮質ホルモン)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 55
End Page 61
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307607
JaLCDOI 10.18926/15152
Title Alternative ステロイド依存性重症難治性喘息における気道反応の特徴
FullText URL 065_040_047.pdf
Author Mifune, Takashi| Kitani, Hikaru| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine|
Abstract Characteristics of airway response in steroid-dependent intractable asthma (SDIA) were examined in 86 asthma patients (43 with SDIA and 43 with non-SDIA) divided into three age groups: 20-39, 40-59 and 60+ years, by observing cellular composition of bronchoalveolar lavage (BAL) fluid and ventilatory function. 1. The level of serum cortisol was significantly lower in patients with SDIA than in those with non-SDIA in all age groups. 2. The proportion of lymphocytes in BAL fluid was significantly decreased in patients with SDIA compared to results in non-SDIA patients in the age between 40-59, and over 60+ years, While BAL neutrophils were significantly increased in SDIA patients compared to results in non-SDIA patients in the age group over 60 years. 3. Of ventilatory parameters, the values of % FVC, FEV(1.0%), % MMF and % V(25) were significantly lower in SDIA patients over the age of 60 compared with non-SDIA subjects of the same age group. These results show that in SDIA patients the proportion of BAL lymphocytes decreases and the proportion of BAL neutrophils increases with aging, and that ventilatory function in SDIA patients also decreases with aging compared to non-SDIA patients.
Abstract Alternative 年齢により3群(20-39才,40-59才,60才以上)に分類された気管支喘息86例(ステロイド依存性重症難治性喘息:SDIA;43例,非SDIA;43例)を対象に,気管支肺胞洗浄液(BALF)中の細胞成分および換気機能よりSDIAにおける気 道反応の特徴を検討した。1.血清コーチゾ-ル値は,SDIA症例において, 非SDIA症例に比べいずれの年齢層においても有意の低値を示した。2.BALF中リンパ球頻度は,40-59才および60才以上のSDIA症例において,同年齢の非SDIA症例に比べ有意の低値を示した。一方,BALF中好中球頻度は,60才以上のSDIA症例で,同年齢層の非SDIA症例に比べ有意に高い値を示 した。また,BALF中好酸球頻度は,いずれの年齢層においても,SDIAと非SDIA症例の間に有意の差は見られなかった。3.換気機能では,% FVC, FEV1.0%,% MMF, % V(25)などの換気パラメーターは,60才以上の SDIA症例において,同年齢層の非SDIA症例に比べて有意の低値を示した。 これらの結果は,40-59才あるいは60才以上のSDIA症例では,非SDIA症例に比べ,BALF中リンパ球頻度の低下,好中球頻度の増加,換気パラメーター値の低下などがより高度に見られることを示している。
Keywords bronchial asthma (気管支喘息) bronchoalveolar cells (気管支肺胞洗浄液中の細胞) ventilatory function (換気機能) glucocorticoids (グルココーチコイド) serum cortiosol levels (血清コーチゾール値)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 40
End Page 47
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307402
JaLCDOI 10.18926/15148
Title Alternative 気管支喘息における末梢血白血球および気管支肺胞洗浄液中の細胞からのヒスタミンおよびロイコトリエンC(4),B(4)遊離と気道過敏性
FullText URL 065_009_016.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine|
Abstract The proportions of cells in bronchoalveolar lavage (BAL) fluid, the release of histamine, leukotrienes C(4) and B(4) from leucocytes and BAL cells, and bronchial reactivity to methacholine were examined in 40 patients with asthma in relation to patient age. 1. The proportions of lymphocytes and neutrophils in BAL fluid were higher in older patients over age 60 than in younger patients between 20 and 49. The proportions of eosinophils and basophilic cells in BAL fluid were higher in younger patients than in older patients, and the difference in the proportion of BAL basophilic cells was significant between the two groups (p<0.05). 2. The release of histamine from BAL cells was significantly higher in younger patients than in older patients (p<0.001). The release of LTC(4) from BAL cells was higher in older patients compared to younger patients. 3. Bronchial reactivity to methacholine was higher in younger patients than in older patients. The number of patients reactive to low concentration of methacholine (390μg/mℓ or less) was larger in younger patients (12/16 ; 75.0%) than in older patients (5/14 ; 35.7%). These results suggest that bronchial hyperresponsiveness changes with aging, accompanied by changes in the release of chemical mediators from BAL cells and in the proportion of BAL cells.
Abstract Alternative 気管支喘息を対象に,気管支肺胞洗浄(BAL)液中の細胞の出現頻度,末梢血白血球およびBAL細胞からのヒスタミン,ロイコトリエンC(4),B(4)遊離,気道過敏性などについて,患者年齢との関連のもとに検討を加えた。1.BAL液中のリンパ球および好中球頻度は,60才以上の老齢症例で,20-49才の若青年症例に比べやや高い傾向が見られたが,推計学的には有意の差は見られなかった。BAL液中の好酸球,好塩基細胞の頻度は,若青年症例で,老年症例に比べて高く,特に好塩基性細胞の頻度には両症例群間に有意の差が見られ(P<0.05)。 2.BAL細胞からのヒスタミン遊離は,若青年症例で,老年症例に比べ有意に多い傾向が見られた(P<0.001)。一方,BAL細胞からのロイコトリエンC(4)遊離は,若青年症例に比べ,老年症例で多い傾向が見られたが,両症例群間に有意の差は見られなかった。3.メサコリンに対する気道の反応性は,全般的に若青年症例で,老年症例に比べより強い傾向を示した。そして,390μg/mℓまたはそれ以下の低濃度のメサコリンに反応を示す症例は,若青年症例では16例中12例(75.0%),老年症例では14例中5例(35.7%)であった。以上の結果より,気道過敏性は,BAL細胞からの化学伝達物質遊離の変化やBAL細胞の頻度の変化とともに,加齢の影響を受けることが明らかとなった。
Keywords BAL cells (BAL細胞) histamine (ヒスタミン) leukotrienes (ロイコトリエン) bronchial hyperresponsiveness (気道過敏性) asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 9
End Page 16
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307646
JaLCDOI 10.18926/15147
Title Alternative 気管支喘息における複合温泉療法と気道炎症反応
FullText URL 065_001_008.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine|
Abstract Efficacy of complex spa therapy was studied in 55 patients with bronchial asthma. Complex spa therapy was effective in 47 (85.5%) of the 55 patients with bronchial asthma : marked efficacy was observed in 15 (27.3%), moderate in 32 (58.2%), slight in 6 (10.9%) and no efficacy in 2 patients (3.6%). Improvement of clinical symptoms and findings by complex spa therapy was more clearly observed in patients with an increased proportion of BAL lymphocytes, neutrophils and eosinophils. These findings suggest that complex spa therapy more affects cell infiltration in the airways than bronchoconstriction induced by chemical mediators. Improvement of ventilatory function represented by FEV1.0% value was higher in patients with a low proportion of BAL neutrophils, suggesting that patients with increased number of BAL neutrophils require longer complex spa therapy than those without BAL neutrophilia.
Abstract Alternative 気管支喘息55例を対象に,複合温泉療法(温泉プール水泳訓練+ヨードゾル吸入+鉱泥湿布療法)を試み,その臨床効果と気道炎症反応との関連について,若干の検討を加えた。1.複合温泉療法の臨床効果では,著効15例(27.3%),有効32例(58.2%),やや有効6例,無効2例であり,明らかに有効と判断された症 例は,55例中47例(85.5%)であった。2.複合温泉療法は,気管支肺胞洗浄液(BALF)中の細胞成分(リンパ球,好中球,好酸球など)が多い症例,すなわち気道炎症反応がより強い症例により有効であった。このことは,複合温泉療法が,単純性の(化学伝達物質による)気管支攣縮よりも,気道炎症反応をともなった病態により強く影響を及ぼすことを示している。3.複合温泉療法による換気機能の改善(1秒量)は,BAL液中の好中球数が少ない症例においてより高度であった。このことは,BAL液中に高度な好中球増多が見られる症例に対しては,より長期的な複合温泉療法が必要であることを示しているものと考えられた。
Keywords complex spa therapy (複合温泉療法) airway inflammation (気道炎症反応) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 1
End Page 8
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307726
JaLCDOI 10.18926/15007
Title Alternative 温泉療法による気管支喘息患者の心理的障害の改善
FullText URL 067_043_049.pdf
Author Yokota, Satoshi| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract To evaluate improvement of mental disorders by spa therapy for 1-2 months, three kinds of psychological examinations, CMI (Cornel Medical Index), SDS (Selfrating Depression Scale) and CAI (Comprehensive Asthma Inventory) tests, were performed in 37 patients with asthma before and after spa therapy. 1. In CMI test, the scores of physical symptoms, respiratory symptoms, and CIJ symptoms significantly decreased after spa therapy. The score of psychical symptoms tended to decrease after the therapy, however, this was not significant. 2. The mean score of the subjects over 40 points in SDS test significantly decreased from 45.7 points before spa therapy to 37.5 after the therapy. 3. Mental disorders evaluated by various categories in CAI test were significantly improved after spa therapy. The average score in CAI test significantly decreased from 37.1 to 27.8 after the therapy. These results demonstrate that psychological disorders in patients with asthma are improved by spa therapy.
Abstract Alternative 気管支喘息に対する温泉療法(1-2ヶ月)による心理的障害の改善を評価するために,3種類の心理学的調査:CMI(Cornel Medical Index),SDS(Selfrationg Depression Scale),CAI(Comprehensive Asthma Inventory)を,気管支喘息患者37例を対象として,入院時と退院時に実施し比較した。①CMIでは,身体的自覚症,呼吸器系症状およびCIJ症状が,温泉療法後に有意に改善した。②SDS値が40以上の症例において,温泉療法後,平均値は45.7から37.5へ有意に減少した。③CAIの種々の心理学的項目により評価した心理的障害は,温泉療法後に有意に改善した。各心理項目の平均値であるCAIスコアは,治療後,37.1から27.8へ有意に低下した。これらの結果から,気管支喘息患者に観察される心理的障害は,温泉療法により改善することが示唆された。
Keywords 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 心理テスト(CMI, SDS, CAI) (CMI test, SDS test, CAI test)
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 43
End Page 49
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307273
JaLCDOI 10.18926/15000
Title Alternative Ⅱ型(細気管支閉塞)喘息と閉塞性細気管支炎における細気管支領域の炎症反応の差
FullText URL 067_014_020.pdf
Author Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract Ventilatory function and inflammatory cells in airways were compared between patients with type Ⅱ (bronchiolar obstruction) asthma and those with obstructive bronchiolitis. 1. Age and age at onset were higher in patients with type Ⅱ asthma than in those with obstructive bronchiolitis. IgE-mediated allergic reaction was observed in patients with type Ⅱ asthma, but not in those with obstructive bronchiolitis. 2. In ventilatory function tests, all ventilatory parameters examined were lower in patients with type Ⅱ asthma compared to those with obstructive bronchiolitis, and the differences were significant in FEV1.0% (p<0.001), % MMF (p<0.02), and V50 (p<0.01). 3. The proportion of BAL neutrophils was very high in type Ⅱ asthma (55.7%) and obstructive bronchiolitis (74.4%), however, this was not significant. 4. Absolute numbers/BAL fluid of total cells, BAL macrophages and BAL neutrophils were significantly higher in patients with obstructive bronchiolitis than in those with type Ⅱ asthma. 5. The results on absolute number/mℓ of BAL cells demonstrated that number of BAL neutrophils markedly larger in patients with obstructive bronchiolitis compared to those with type Ⅱ asthma. These results show that high proportion of BAL neutrophils was observed in the two respiratory diseases, however, the degree of inflammation in airways was markedly greater in obstructive bronchiolitis.
Abstract Alternative Ⅱ型喘息と閉塞性細気管支炎の臨床的特徴について,換気機能および気道炎症反応を中心に検討を加えた。1.年齢,および発症年齢とも閉塞性細気管支炎に比べⅡ型喘息において高い傾向が見られた。IgE系反応はⅡ型喘息では観察されたが,閉塞性細気管支炎では見られなかった。2.換気機能では,測定された全ての換気パラメーターにおいて,その値は閉塞性細気管支炎に比べⅡ型喘息でより低い値を示し,FEV1.0%,% MMFおよび% V50では有意の差が見られた。3.BAL液中好中球頻度は,Ⅱ型喘息(55.7%),閉塞性細気管支炎(74.4%)いずれにおいても高い値を示したが,両者間に有意の差は見られなかった。4.一方,BAL液中の絶対数では,Ⅱ型喘息に比べ,閉塞性細気管支炎において,総細胞数,マクロファージおよび好中球数が有意の高値を示した。5.また,lmℓあたりの細胞数の比較でも,閉塞性細気管支炎で好中球数が著明な高値を示した。これらの結果より,この2疾患では気道内好中球増多は同様に見られるものの,その気道炎症の程度は明らかに閉塞性細気管支炎でより高度であることが示された。
Keywords Ⅱ型喘息 (Type Ⅱasthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 換気機能 (Ventilatory function) BAL好中球 (BAL neutrophiIs) IgE系反応 (IgE-mediated allergy)
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 14
End Page 20
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307471
JaLCDOI 10.18926/14987
Title Alternative Clinical effect of spa therapy on lumbargo
FullText URL 068_051_058.pdf
Author Okamoto, Makoto| Ashida, Kozo| Yamamoto, Kazuhiko| Iwagaki, Naofumi| Tsugeno, Hirofumi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract 腰痛症患者12例を対象に温泉療法の臨床効果について検討した。臨床効果の判定は,日本整形外科学会の腰痛治療成績判定基準に基づき,自覚症状,他覚症状,及び日常生活動作などの項目を中心に,治療前後で比較検討した。その結果,自覚症状,日常生活動作,総計では,治療前に比べ治療後に有意の改善がみられた。また改善指数や改善率での検討でも温泉療法の有効性が示唆された。年齢別(60才以上と60才未満),入院期間(80日以上と80日未満)別の 検討では,65才未満の症例,80日以上の入院の症例において,改善指数,改善率が,有意差はみられなかったもののより高い傾向がみられた。
Abstract Alternative Clinical effect of spa therapy was evaluated in 12 patients with lumbargo by a scoring system based on the standard judgement of therapy for lumbargo by Japanese Society of Orthopedics. The score for each category of subjective symptoms, objective symptoms, daily life activity, and disorder of urinary bladder, and total score calculated from each score were compared before and after spa therapy. A significant improvement of subjective symptoms, daily life activity, and total score was observed after spa therapy. However objective symptom was not significantly improved. The effects of spa therapy was larger in patients under age of 65, and in those who had long-term spa therapy more than 80 days during their admission. The results suggest that spa therapy IS effective for patients with lumbargo.
Keywords 腰痛症 (lumbargo) 温泉療法 (spa therapy) 腰痛治療判定基準 (scoring system based on the standard judgement of therapy for lumbargo)
Publication Title 岡大三朝分院研究報告
Published Date 1997-12
Volume volume68
Start Page 51
End Page 58
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308321
JaLCDOI 10.18926/14979
Title Alternative 気管支喘息症例における臨床的特徴と鼻腔・副鼻腔のCT所見の関連について
FullText URL 068_034_040.pdf
Author Mifune, Takashi| Yamamoto, Kazuhiko| Iwagaki, Naofumi| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract Extent of nasal and maxillary mucosa lesion was estimated in 26 asthmatics using computed tomographic scan in relation to clinical features of the disease. 1. No significant differences were present in nasal mucosal thickening between atopic and non-atopic subjects. No significant differences were also present in occupancy rate of mucosa in maxillary sinuses between the two asthma types. 2. Nasal mucosal thickening was not significant different between subjects with steroid-dependent intractable asthma (SDIA) and those without SDIA. Maxillary mucosal lesions were more extensive in subjects with SDIA than in those without SOIA. However, no significant differences were observed in occupancy rate between the two types. 3. No significant differences were observed in nasal mucosal thickenings between in subjects with and without aspirin-induced asthma (AlA). Although maxillary mucosa lesion in subjects with AlA was more extensive than that in those without AlA, the differences was not significant. 4. There was not any correlation between nasal mucosal thickening and amount of expectoration per day. However, significant differences were observed in maxillary sinus lesion between subjects with less amount (<50mℓ/day) and those with large amount of expectoration (100mℓ/day≦)(p<0.002), and between subjects with moderate amount (50-99mℓ/ day) and those with large amount of expectoration (p<0.002). The results might suggest that in asthmatics with large amount of expectoration, sinus diseases affect pathophysiology of asthma, and asthmatics with large amount of expectoration should have therapy for sinus disease to improve asthmatic status.
Abstract Alternative 気管支喘息26症例において喘息の臨床的特徴と,鼻腔・上顎洞のCT所見の関連について検討を加えた。1.鼻腔粘膜肥厚はアトピー症例,非アトピー症例間で有意な差は認められなかった。上顎洞における粘膜肥厚比率(1slice上の上顎洞面積に対し,上顎洞粘膜が占める割合)も,アトピー・非アトピーで差は認められなかった。2.ステロイド依存群・非依存群においても,鼻腔粘膜肥厚・上顎洞粘膜肥厚に有意な差は認められなかった。3.アスピリン喘息症例においては,非アスピリン喘息症例に比べ,上顎洞粘膜肥厚が顕著であっ たが有意ではなかった。鼻腔粘膜肥厚は2群間で差は認められなかった。4.発作時の一日喀痰量との関連では一日喀痰量が100mℓ以上の症例群では,喀痰量が50mℓ以下の群・50-100mℓの群に比較して有意に上顎洞粘膜肥厚比率が高値を示した。鼻腔粘膜比率に関しては3群間で有意な差を認めなかった。以上の結果から,喀痰量の多い気管支喘息症例では,その病態に副鼻腔病変が影響を及ぼしている可能性が考えられ,副鼻腔病変に対する治療により,気管支喘息が改善する可能性が考えられた。
Keywords bronchial asthma sinusitis nasal disease CT scan expectoration
Publication Title 岡大三朝分院研究報告
Published Date 1997-12
Volume volume68
Start Page 34
End Page 40
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308538
JaLCDOI 10.18926/14978
Title Alternative Effect of spa therapy on peak expiratory flow in patients with bronchial asthma
FullText URL 068_028_033.pdf
Author Mifune, Takashi| Yamamoto, Kazuhiko| Iwagaki, Naofumi| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract 気管支喘息に対する温泉療法の効果をピークフローメーターを用いて継時的(第1週,第5過,第9週)に検討した。1.軽症・中等症では,第5週で有意にピークフロー (PEF)値は上昇した.重症気管支喘息例では第9週に有意な改善を認めた。2.20%以上のPEF値の改善を認めた症例の割合は第5週では,軽症・中等症・重症群で40~50%であったが,第9週では軽症群で80%,重症群で54.5%に増加していた。中等症群では第5週と同等であった。3.第1週のPEFが200(L/m)以下の症例では第5週,第9過とPEFの有意な改善を示したが,200<PEF≦300の症例,300<PEFの症例では有意な改善は認められなかった。4.PEF≦200(L/m)の症例群において,20%以上のPEFの改善を示す症例は,第5週で57%,第9週で69%と高率であった。200<PEF≦300の症群,300PEFの症例群では第9週で40%以上の症例が20%以上のPEFの改善を示した。
Abstract Alternative The aim of this study was to investigate effects of spa therapy on peak expiratory flow (PEF) in patients with bronchial asthma. Morning PEF metry was studied in fifty asthmatics who had spa therapy (swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy) for 5 - 9 weeks. Mean values of morning PEF at the initial stage, 5 and 9 weeks after spa therapy were assessed. In mild and moderate asthmatics, PEF significantly improved 5 weeks after spa therapy. In severe asthmatics, PEF showed significant increase 9 week. The number of subjects with PEF improvement more over 20%, compared with the intial value of PEF, were 50% at 5 weeks and 80% at 9 weeks after spa therapy in mild asthmatics. In moderate asthmatics, however, the number little changed between 5 (39.3%) and 9 weeks (38.9%) after the therapy. In severe asthmatics, 57.1% at 5 and 68.8% at 9 weeks. In asthmatics with the initial value of PEF<200L/m (low PEF group), the value showed significant increase 5 and 9 weeks after the therapy compared with the initial value. In asthmatics with the initial values of 200≦PEF<300 (middle PEF group) and 300≦PEF (high PEF group), the values showed no significant increase. The number of subjects with PEF improvement more than 20% showed a tendency to increase 9 weeks in low, middle and high PEF group, compared to the value after spa therapy (57.1% to 68.8%, 21.4% to 50% and 35.7% to 42.9%, respectively ).
Keywords bronchial asthma spa therapy peak expiratory flow (PEF)
Publication Title 岡大三朝分院研究報告
Published Date 1997-12
Volume volume68
Start Page 28
End Page 33
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308119
JaLCDOI 10.18926/14959
Title Alternative n-3系脂肪酸食の気管支喘息に対する臨床効果:n-6系脂肪酸との比較
FullText URL 069_040_048.pdf
Author Okamoto, Makoto| Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Tanizaki, Yoshiro| Kataoka, Mikio| Harada, Mine|
Abstract N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation.
Abstract Alternative 気道への炎症性白血球の集合が気管支喘息の病態に関わっている。魚油などのn-3系脂肪酸が白血球の機能を抑制することにより気管支喘息患者に良好な効果をもたらし,薬剤の必要性を減じたとの報告がなされている。α-リレノン酸を豊富に含有するエゴマ油食の効果を調べるため,気管支喘息患者23名に2コースの食事-リノール酸の豊富なコーン油食を2週間摂取後,エゴマ油食を2週間-を摂取してもらった。喘息患者は2コースの食事間のロイコトリエンB4(LTB4),CA(LTC4),B5(LTB5)の変化から2群-1群は食事に対し感受性のある群,もう1つは感受性の無い群-に分類した。我々はこの2群を臨床的に検討したところ,ピークフロー(PEF),1秒量(FEV10),IgE,性別,肥満率(OⅠ),血清総コレステロール,アルブミン,低比重リポ蛋白(LDL)-コレステロール,β-リポ蛋白,リン脂質において2群間に有意差が認められた。今回の研究から,これらの因子が,喘息患者において,LTB4,LTC4,LTB5の産生に対する食事療法の効果に影響を及ぼしていることが示唆された。
Keywords n-3系脂肪酸 (n-3 fatty acids) エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) LTB4 LTC4
Publication Title 岡大三朝分院研究報告
Published Date 1998-12
Volume volume69
Start Page 40
End Page 48
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308199
JaLCDOI 10.18926/14936
Title Alternative 腰椎MRI画像と腰痛の関係
FullText URL 070_067_072.pdf
Author Takata, Shingo| Yumoto, Eiichirou| Okamoto, Makoto| Tsugeno, Hirofumi| Harada, Seishi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Harada, Mine|
Abstract The purpose of this study was to examine the potential role of magnetic resonance imaging (MRI) in the evaluation of low back pain (LBP). The study group, 19 patients with low back pain (2 subjects aged 32-39 years and 17 aged 59-78), underwent MRI of the lumbar spine. Disc degeneration at L4/5 was the most common finding (68.4%). Overall in present study, all patients with LBP had abnormalities around the lumbar spine (evidence of disc degeneration, deformity of lumbar spine, disc bulging or protrusion, facet hypertrophy, nerve root compression and so on).
Abstract Alternative この研究の目的は腰痛評価におけるMRIの役割を検討することであった。対象は腰痛を訴え腰椎MRIを受けた19名(32歳から39歳2名,59歳から78歳17名)であった。椎間板変成はL4/5levelで最も多く認められた(68.4%)。本研究において腰痛を有する全患者に腰椎の異常(椎間板変性,disc bulging, protrusion, facet hypertrophy,神経根圧迫,腰椎変形など)を認めた。
Keywords MRI (Magnetic resonance imaging) 腰椎 (Lumbar spine) 椎間板変性 (Disc disease)
Publication Title 岡大三朝分院研究報告
Published Date 1999-12
Volume volume70
Start Page 67
End Page 72
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308559
JaLCDOI 10.18926/14933
Title Alternative 気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子
FullText URL 070_043_052.pdf
Author Okamoto, Makoto| Mitsunobu, Fumihiro| Ashida, Kozo| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Harada, Seishi| Takada, Shingo| Tanizaki, Yoshiro| Kataoka, Mikio| Niiya, Kenji| Harada, Mine|
Abstract Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation.
Abstract Alternative a-リノレン酸の豊富なエゴマ油の食事は気管支喘息患者の白血球ロイコトリエン(LT)産生能を抑制する。気管支喘息患者の内,エゴマ油食によりLTC4の産生が抑制された群(A群)と抑制されない群(B群)の臨床データを比較することにより,気管支喘息患者の白血球ロイコトリエン産生能に影響する因子を検討した。A群はコーン油(n-6系脂肪酸)の豊富な食事後,白血LTB4,LTC4の産生能が増加し,エゴマ油(n-3系脂肪酸)の豊富な食事後LTB4,LTC4の産生能が減少した。これらの変化はB群では認められなかった。A群のIgE値,ピークフロー(PEF)値はB群に比し,有意に高値であった。またLDL-コレステロール,β-リポ蛋白,リン脂質はA群ではB群に比し,有意に低値であった。これらの結果はエゴマ油の豊富な食事のn-3系脂肪酸によるLTB4,LTC4の産生能の抑制に関して2群の気管支喘息患者群間に臨床データの相違があることを示唆している。
Keywords エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) ロイコトリエン (leukotrienes) IgE 脂質代謝 (lipometabolism)
Publication Title 岡大三朝分院研究報告
Published Date 1999-12
Volume volume70
Start Page 43
End Page 52
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308623
JaLCDOI 10.18926/14926
Title Alternative 気管支喘息症例における気道過敏性と鼻腔・副鼻腔疾患の関係に関する検討
FullText URL 070_028_035.pdf
Author Mifune, Takashi| Takata, Shingo| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Harada, Seishi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Harada, Mine|
Abstract Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics. The extent of nasal and sinus lesion was quantified in 17 patients with bronchial asthma, and their relationships to atopic status, asthma severity and bronchial hyperresponsiveness were evaluated in this study. Opacification degree of maxillary sinuses and nasal mucosa thickening were quantified using CT scans. The opacification degree was evaluated as (total opacification area)/(total maxillary sinus area). Although the opacification degree of maxillary sinuses in atopic patients showed no significant difference compared with that in non-atopic patients, maximum nasal mucosa thickening in atopic patients had a significant difference compared with that in non-atopic patients (p=0.028). In severe asthmatics, the opacification degree of maxillary sinuses was significantly more prominent compared with those in moderate and mild asthmatics (p=0.0005, p=0.036, respectively). Significantly marked nasal mucosa thickening was recognized in mild asthmatics compared with that in moderate asthmatics (p=0.0462). Regarding bronchial hyperresponsiveness, a significant correlation between Dmin and the opacification degree of maxillary sinuses was observed (rs= -0.551, p=0.0276). Nasal mucosa thickening had no correlation with bronchial hyperresponsiveness. The results suggest that sinusitis may affect bronchial hyperresponsiveness and asthma severity. Treatment of sinusitis may lead to improvement of asthma symptoms.
Abstract Alternative 鼻腔・副鼻腔疾患はしばしば気管支喘息症例に合併が認められ,喘息症例の下気道病態に影響を及ぼしている可能性が考えられる。今回,気管支喘息17例において,CTを用いて上顎洞の不透明化率・鼻腔粘膜肥厚を計測し,アトピー性の有無,喘息の重症度,気道過敏性との関係を検討した。上顎洞不透明化率は全上顎洞面積の総計に対する不透明化領域面積総計として計算を行った。上顎洞不透明化率はアトピー性の有無で差は認められなかったが,鼻腔粘膜はアトピー性喘息症例で有意に肥厚していた。重症気管支喘息における上顎 洞不透明化率は,中等症および軽症喘息症例に比べ有意に高値であった。鼻腔粘膜肥厚は中等症喘息症例に比べ,軽症症例で有意に肥厚していた。気道過敏性(Dmin)は上顎洞不透明化率とのあいだに弱い負の相関が認められた(rs=-0.551,p=0.0276).鼻粘膜肥厚と気道過敏性は相関が認められなかった。今回の結果から副鼻腔病変が気道過敏性・喘息重症度に影響を及ぼしている可能性が考えられ.副鼻腔疾患の治療により喘息症状の改善に繋がる可能性が考えられた。
Keywords 気管支喘息 (bronchial asthma) 副鼻腔炎 (sinusitis) CT所見 (CT findings) 気道過敏性 (hyperresponsiveness)
Publication Title 岡大三朝分院研究報告
Published Date 1999-12
Volume volume70
Start Page 28
End Page 35
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308098
JaLCDOI 10.18926/14911
Title Alternative A case of systemic lupus erythematosus (SLE) associated with disseminated intravascular coagulation (DIC)
FullText URL 071_068_072.pdf
Author Takata, Singo| Okamoto, Makoto| Tsugeno, Hirofumi| Harada, Seishi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Niiya, Kenji| Harada, Mine|
Abstract 播種性血管内凝固症候群(DIC)を合併した全身性エリテマトーデス(SLE)を経験したので報告する。症例は73歳女性。64歳時慢性関節リウマチ(RA)と診断された。1999年1月食欲低下を訴え当科受診した。血小板減少、FDP高値、PT上昇等よりDIC発症を疑った。膠原病では凝固系の異常を認めるが、本症例では凝固系が完進しDICを来したと考えられた。 本症例はリウマチ因子陽性であったが、朝のこわばり等典型的なRAの所見に乏しく他の膠原病の合併を疑い、腎障害、血小板減少、抗Sm抗体、抗核抗体陽性よりSLEと診断した。
Abstract Alternative A case of disseminated intravascular coagulation (DIC) in a patient with systemic lupus erythematosus (SLE) was described. A 73-year-old female was diagnosed as having rheumatoid arthritis when she was 64 years old. In Jan, 1999, the patient was admitted to our hospital with the complaint of loss of appetite. She was suspected of DIC because of thrombocytopenia, increased fibrin degradation product and prolonged prothrombin test. Abnormality in coagulation system is recognized in collagen disease. In this case coagulation system was activated and DIC occurred. In this case rheumatoid factor was positive. But she was suspected of complicating other collagen disease because she was poor in typical characteristics of rheumatoid arthritis, such as morning stiffness. SLE was diagnosed on the basis of renal injury, thrombocytopenia, positive anti-Sm antibody and positive antinuclaer antibody in this case.
Keywords 慢性関節リウマチ (Rheumatoid arthritis) 全身性エリテマトーデス (Systemic lupus erythematosus) 播種性血管内凝固症候群 (Disseminated intravascular coagulation syndrome)
Publication Title 岡大三朝分院研究報告
Published Date 2001-02-01
Volume volume71
Start Page 68
End Page 72
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002308643
JaLCDOI 10.18926/14909
Title Alternative 脂肪の変化と関連した気管支喘息に対するn-3系脂肪酸食の効果 ― n-6系脂肪酸との比較
FullText URL 071_050_058.pdf
Author Okamoto, Makoto| Mitsunobu, Fumihiro| Ashida, Kozo| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Takata, Shingo| Tanizaki, Yoshiro| Harada, Mine|
Abstract N-3 fatty acids have been reported to be effective for asthma. In the present study, the effects of perilla seed oil (n-3 fatty acids) on asthma were compared with the effects of corn oil (n-6 fatty acids) in terms of pulmonary function, lipometabolism and the generation of leukotriene C4 (LTC4) by leucocytes. A total of 28 asthmatic patients were randomly divided into two groups : Group A patients (15 subjects) consumed perilla seed oil-rich supplementation, while Group B patients (13 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTC4 by leucocytes, respiratory function and the serum levels of lipids were compared between the two groups. The generation of LTC4 by leucocytes decreased significantly in Group A subjects following perilla seed oil-rich supplementation for 2(P < 0.05) and 4 weeks(P < 0.01). A significant difference in the generation of LTC4 was observed between the two groups after different dietary supplementations for 4 weeks (P < 0.05). Significantly increased values for PEF (P < 0.01), FVC (P < 0.05) and FEV1.0 (P < 0.05) were found in Group A subjects following perilla seed oil supplementation for 4 weeks, compared with the initial value prior to supplementation. A significant decrease in the serum level of total cholesterol, LDL-cholesterol and phospholipid was detected in Group A subjects following perilla seed oil supplementation for 4 weeks. The present results suggest that peril la seed oil-rich supplementation is effective in the treatment of asthma in terms of its ability to suppress LTC4 generat ion by leucocytes, and in inducing an improvement in pulmonary function associated with changes in the serum level of lipids.
Abstract Alternative n-3系脂肪酸は喘息に有効であることが報告されている。今回、エゴマ油(n-3系脂肪酸)の喘息に対する効果を呼吸機能、イコトリエンC4(LTC4)産生能の観点から、コーン油(n-6系脂肪酸)のそれと比較した。28例の喘息患者を無作為に2群に分け、A群(15例) はエゴマ油食を、B群(13例)はコーン油食をそれぞれ4週間摂取した。白血球LTC4産生能、呼吸機能、血清脂質を2群間で比較した。白血球LTC4産生能はエゴマ抽食を摂取したA群で2週後(P < 0.05)、4過後(P < 0.01)に有意に低下した。食事摂取4過後に岳群間でLTC4産生能に有意差が認められた(P < 0.05)。エゴマ油食を4過摂取したA群ではピークフロー(P < 0.05)、肺活量(P < 0.01)、1秒量(P < 0.05)が食事摂取前に比し、有意に増加した。またA群ではエゴマ坤食摂取4週後に血清総コレステロール値、LDL-コレステロール値、リン脂質の有意な低下がみられた。こ れらの結果より、エゴマ油食は白血球LTC4産生能を抑制することにより、呼吸機能を改善し、血清脂質の変化と関連して、喘息の治療に有効であることが示唆された。
Keywords perilla seed oil (エゴマ抽) a -1inolenic acid (α-リノレン酸) leukotriene C4 (ロイコトリエンC4) respiratory function (呼吸機能) 脂質代謝
Publication Title 岡大三朝分院研究報告
Published Date 2001-02-01
Volume volume71
Start Page 50
End Page 58
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308088
JaLCDOI 10.18926/14907
Title Alternative 気管支喘息症例における末梢血白血球のロイコトリエンC4産生能とロイコトリエン受容体括抗薬プランルカストの効果に関する検討
FullText URL 071_036_041.pdf
Author Mifune, Takashi| Takada, Shingo| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Harada, Mine|
Abstract The correlation between the efficacy of 4-weeks administration with pranlukast, leukotriene receptor antagonist, and LTs generation by peripheral leukocytes were evaluated in 18 patients with mild-persistent asthma. The efficacy of pranlukast administration was assessed by symptom, morning PEF and pulmonary function. Pranlukast were effective in 12/18(67%) patients. In those patients, LTC4 generation before pranlukast administration was significantly high, compared with that in pranlukast-ineffective patients. LTC4 generation decreased after 4-weeks administration with pranlukast in effective patients. In ineffective patients, however, LTC4 generation increased after 4-weeks administration. LTB4 had shown no significant difference between effective and ineffective patients before administration, and LTB4 decreased after 4-weeks in both groups. Proport ion of peripheral eosinophi Is in effective patients were higher than that in ineffective patients, however not significant. After 4-weeks, proportion of eosinophi Is was decreased in effective patients and increased in ineffective patients. These findings suggest that pranlukast is effective for patients with high LTC4 generation and has the effect to suppress the accumulation of eosinophils in such patients.
Abstract Alternative 軽症気管支喘息18例にロイコトリエン受容体桔抗薬プランルカストを4週間投与し,その効果と末梢血白血球からのLTC4,LTB4産生能の関係を検討した.プランルカストの効果は臨床症状,起床時ピークフロー値,肺機能の変化によって判定し,効果群,非効果群の2群に分類した.18例中12例(67%)の症例がプランルカスト投与により,臨床症状の軽減,ピークフロー値の増加,肺機能の改善が認められた.効果群におけるプランルカスト投与前のLTC4値は,非効果群のLTC4値に比較して有意に高値であった.4週間の投与後には 効果群ではLTC4値は減少し,非効果群では増加した.両群のLTB4値はプランルカスト投与前で有意な差は認められず,投与後には両群で減少した.投与前の好酸球分画は,効果群において非効果群に比べ高値であったが,有意な差は認められなかった.4週間の投与後,効果群においては好酸球は減少し,非効果群においては増加した.以上の結果より,プランルカストは末梢血白血球のLTC4産生能が高い症例において効果的であり,好酸球集積を抑制する作用を有すると考えられる.
Keywords bronchial asthma pranlukast leukotriene receptor antagonist LTC4
Publication Title 岡大三朝分院研究報告
Published Date 2001-02-01
Volume volume71
Start Page 36
End Page 41
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308269