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ID 21138
Eprint ID
21138
FullText URL
Title Alternative
The Effect of Thermal Spring Water on Drug Absorption in Special Reference to Aspirin and Indomethacin
Author
Okamoto, Teruko
Hirano, Mitsuhiro
Furuno, Katsushi
Abstract
It is thought that a drug reacts differently with media taken internally. The solubility of Aspirin is assured 600μg/ml in 30min. with Misasa spring water, whereas 400μg/ml with plain water. The parallel difference of 200μg/ml follows 10 min. thereafter. Maximum serum concentratin of 200μg/ml is obtained 2 hours after the internal use of Aspirin with Misasa spring water in parallel difference of 20μg/ml with plain water. In the case of Indomethacin intake, maximum serum concentration of 1.5μg/ml is obtained in 2 hours with plain water, whereas maximum serum concentration of 1μg/ml is obtained in the same period with Misasa spring water. However, the difference of 0.25μg/ml in serum concentration between the media internally taken is seen initially and after 4 hours under high concentration of Indomethacin. We, therefore, assume tentatively that the effect of Aspirin and Indomethacin is supposed to be enhanced with Misasa spring water taken internally.
Note
原著論文 (Original Papers)
Published Date
1982-03-25
Publication Title
岡山大学温泉研究所報告
Publication Title Alternative
Papers of the Institute for Thermal Spring Research, Okayama University
Volume
volume52
Publisher
岡山大学温泉研究所
Publisher Alternative
Institute for Thermal Spring Research, Okayama University
Start Page
45
End Page
50
ISSN
0369-7142
NCID
AN00032853
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc